5 documents found, page 1 of 1
Umbilical-Cord-Derived Mesenchymal Stromal Cells Modulate 26 Out of 41 T Cell S...
Laranjeira, Paula; Dos Santos, Francisco; Salvador, Maria João; Simões, Irina N.; Cardoso, Carla M. P.; Silva, Bárbara M.; Henriques-Antunes, HelenaSystemic sclerosis (SSc) is an immune-mediated disease wherein T cells are particularly implicated, presenting a poor prognosis and limited therapeutic options. Thus, mesenchymal-stem/stromal-cell (MSC)-based therapies can be of great benefit to SSc patients given their immunomodulatory, anti-fibrotic, and pro-angiogenic potential, which is associated with low toxicity. In this study, peripheral blood mononucle...
Assessment of calcinosis in Portuguese patients with systemic sclerosis: a mult...
Samões, Beatriz; Guimarães da Fonseca, Diogo; Beirão, Tiago; Costa, Flávio; Vieira, Romana; Terroso, Georgina; Ferreira, Raquel Miriam; Nicolau, RafaelaIntroduction/objectives: The study aims to define the clinical and subclinical calcinosis prevalence, the sensitivity of radiographed site and clinical method for its diagnosis, and the phenotype of Portuguese systemic sclerosis (SSc) patients with calcinosis. Method: A cross-sectional multicenter study was conducted with SSc patients fulfilling Leroy/Medsger 2001 or ACR/EULAR 2013 classification criteria, regi...
Gender differences in clinical features and outcomes of a Portuguese systemic s...
Freitas, Raquel; Martins, Patrícia; Dourado, Eduardo; Santiago, Tânia; Guimarães, Francisca; Fernandes, Bruno Miguel; Garcia, Salomé; Samões, BeatrizEvidence for the role of sex in the clinical manifestations of systemic sclerosis (SSc) patients is emerging. Some multicenter cohorts have shown that male SSc patients have more severe disease and worse survival. To assess the differences in clinical manifestations and survival in Portuguese SSc patients according to gender. Data from male and female adult SSc patients included in the Rheumatic Diseases Portug...
Exercise echocardiography for the assessment of pulmonary hypertension in syste...
Baptista, Rui; Serra, Sara; Martins, Rui; Teixeira, Rogério; Castro, Graça; Salvador, Maria João; Silva, José António Pereira da; Santos, LélitaBackground: Pulmonary arterial hypertension (PAH) complicates the course of systemic sclerosis (SSc) and is associated with poor prognosis. The elevation of systolic pulmonary arterial pressure (sPAP) during exercise in patients with SSc with normal resting haemodynamics may anticipate the development of PAH. Exercise echocardiography (ExEcho) has been proposed as a useful technique to identify exercise-induced...
Hodgkin's disease presenting with pyrexia of unknown origin
Branco, Vitor; Salvador, Maria João; Silva, Mário Rui; Martins, Paulo; Carvalho, Armando; Almiro, Eurico; Porto, Armandoln Hodgkin's disease, the anatomical extension of the disease and the histological sub type are the major determinants of the forms of disease presentation. Frequently, clinical manifestations have low specificity and it is difficult to suspect tbe diagnosis. A clinical case is reported of abdominal Hodgkin's disease of tbe lympbocyte depleted type, that presented initially with pyrexia of unknown origin, ...