4 documents found, page 1 of 1
Fabrication of a tissue engineering mat by emulsion-based electrospinning of po...
Alizadeh, Sanaz; Pezeshki-Modaress, Mohamad; Kundu, Subhas C; Gholipourmalekabadi, Mazaher; Samadikuchaksaraei, AliThe development of electrospun tissue engineering scaffolds using silk fibroin and polycaprolactone (PCL) has been reported. The challenge in this system is the design of a suitable solvent with high stability. In this study, a mat was electrospun with PCL-fibroin fibers using an emulsion consisting of PCL and a blend of fibroin and polyethylene oxide (PEO). The effects of different concentrations of fibroin an...
Ancient fibrous biomaterials from silkworm protein fibroin and spider silk blen...
Johari, Narges; Khodaei, Azin; Samadikuchaksaraei, Ali; Reis, R. L.; Kundu, Subhas C; Moroni, LorenzoSilkworm silk protein fibroin and spider silk spidroin are known biocompatible and natural biodegradable polymers in biomedical applications. The presence of β-sheets in silk fibroin and spider spidroin conformation improves their mechanical properties. The strength and toughness of pure recombinant silkworm fibroin and spidroin are relatively low due to reduced molecular weight. Hence, blending is the foremost...
Silk fibroin for skin injury repair: Where do things stand?
Gholipourmalekabad, MMazaher; Sapru, Sunaina; Samadikuchaksaraei, Ali; Reis, R. L.; Kaplan, David L.; Kundu, Subhas CSeveral synthetic and natural materials are used in soft tissue engineering and regenerative medicine with varying degrees of success. Among them, silkworm silk protein fibroin, a naturally occurring protein-based biomaterial, exhibits many promising characteristics such as biocompatibility, controllable biodegradability, tunable mechanical properties, aqueous preparation, minimal inflammation in host tissue, l...
Silk fibroin/amniotic membrane 3D bi-layered artificial skin
Gholipourmalekabadi, Mazaher; Samadikuchaksaraei, Ali; Seifalian, Alexander M.; Urbanska, Aleksandra M.; Ghanbarian, Hossein; Hardy, John G.Burn injuries have been reported to be an important cause of morbidity and mortality and they are still considered as unmet clinical need. Although there is a myriad of effective stem cells that have been suggested for skin regeneration, there is no one ideal scaffold. The aim of this study was to develop a three-dimensional (3D) bi-layer scaffold made of biological decellularized human amniotic membrane (AM) w...