3 documents found, page 1 of 1
Serum Pantetheinase/Vanin Levels Regulate Erythrocyte Homeostasis and Severity ...
Rommelaere, Samuel; Millet, Virginie; Rihet, Pascal; Atwell, Scott; Helfer, Emmanuèle; Chasson, Lionel; Beaumont, Carole; Chimini, GiovannaTissue pantetheinase, encoded by the VNN1 gene, regulates response to stress, and previous studies have shown that VNN genes contribute to the susceptibility to malaria. Herein, we evaluated the role of pantetheinase on erythrocyte homeostasis and on the development of malaria in patients and in a new mouse model of pantetheinase insufficiency. Patients with cerebral malaria have significantly reduced levels of...
Impact of a training course on the quality of malaria diagnosis by microscopy i...
Moura, Sofia; Fançony, Cláudia; Mirante, Clara; Neves, Marcela; Bernardino, Luís; Fortes, Filomeno; Sambo, Maria do Rosário; Brito, MiguelBackground: In Angola, malaria is an endemic disease having a major impact on the economy. The WHO recommends testing for all suspected malaria cases, to avoid the presumptive treatment of this disease. In malaria endemic regions laboratory technicians must be very comfortable with microscopy, the golden standard for malaria diagnosis, to avoid the incorrect diagnosis. The improper use of medication promotes dr...
Cerebral malaria and post-malarial neurological syndrome
Sambo, Maria do Rosário; Borges, Augusta; Borges, FernandoThe cerebral form of severe Plasmodium falciparum malaria is the commonnest and most important of the many neurologícal manifestations and complicatíons of malaria. The purpose of this article is to review, in some detail, our knowledge of cerebral malaria. By definition, cerebral malaria requires coma to persist for at least 30 minutes, alter a generalized convulsion, to make the distinction from transient pos...