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tRNA-modifying enzyme mutations induce codon-specific mistranslation and protei...
Tavares, Joana F.; Davis, Nick K.; Poim, Ana; Reis, Andreia; Kellner, Stefanie; Sousa, Inês; Soares, Ana R.; Moura, Gabriela M. R.; Dedon, Peter C.Protein synthesis rate and accuracy are tightly controlled by the cell and are essential for proteome homoeostasis (proteostasis); however, the full picture of how mRNA translational factors maintain protein synthesis accuracy and co-translational protein folding are far from being fully understood. To address this question, we evaluated the role of 70 yeast tRNA-modifying enzyme genes on protein aggregation an...
Date: 2020
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Origin: RIA - Repositório Institucional da Universidade de Aveiro