12 documents found, page 1 of 2
Urinary hydration biomarkers and water sources in older adults with neurocognit...
Queiros, C; Machado, FB; Barros, D; Sampaio, J; Sampaio, A; Barros, Renata; Moreira, Pedro; Ribeiro, O; Joana Carvalho; Padrão, PatríciaThe risk of dehydration in older adults with neurocognitive disorder (NCD) is controversial. The purpose of this study was to assess hydration status, its determinants, and water intake sources in older adults with NCD. A sample of 30 participants (>= 60 years) was included. Sociodemographic, clinical data and one 24-h urine sample were collected. Urinary osmolality, sodium, potassium, volume, and creatinine we...
Genomic imbalances defining novel intellectual disability associated loci
Lopes, F; Torres, F; Soares, G; Barbosa, M; Silva, J; Duque, F; Rocha, M; Sá, J; Oliveira, G; Sá, MJ; Temudo, T; Sousa, S; Marques, C; Lopes, SBackground: High resolution genome-wide copy number analysis, routinely used in clinical diagnosis for several years, retrieves new and extremely rare copy number variations (CNVs) that provide novel candidate genes contributing to disease etiology. The aim of this work was to identify novel genetic causes of neurodevelopmental disease, inferred from CNVs detected by array comparative hybridization (aCGH), in a...
Patterns of Default Mode Network Deactivation in Obsessive Compulsive Disorder
Gonçalves, ÓF; Soares, JM; Carvalho, S; Leite, J; Ganho-Ávila, A; Fernandes-Gonçalves, A; Pocinho, F; Carracedo, A; Sampaio, AThe objective of the present study was to research the patterns of Default Mode Network (DMN) deactivation in Obsessive Compulsive Disorder (OCD) in the transition between a resting and a non-rest emotional condition. Twenty-seven participants, 15 diagnosed with OCD and 12 healthy controls (HC), underwent a functional neuroimaging paradigm in which DMN brain activation in a resting condition was contrasted with...
Cerebral and cerebellar MRI volumes in Williams syndrome
Osório, A; Soares, JM; Prieto, MF; Vasconcelos, C; Fernandes, C; Sousa, SB; Carracedo, A; Gonçalves, OF; Sampaio, AIndividuals with Williams syndrome (WS) present a set of cognitive, affective and motor symptoms that resemble those of patients with lesions to the cerebellum. Although there is some evidence for overall structural alterations in this brain region in WS, explorations on cerebellar white matter and cerebellar cortex volumes remain rather neglected. We aimed to compare absolute and relative cerebellar volumes, a...
Brain activation of the defensive and appetitive survival systems in obsessive ...
Gonçalves, OF; Soares, JM; Carvalho, S; Leite, J; Ganho, A; Fernandes-Gonçalves, A; Frank, B; Pocinho, F; Relvas, J; Carracedo, A; Sampaio, ASeveral studies have shown that basic emotions are responsible for a significant enhancement of early visual processes and increased activation in visual processing brain regions. It may be possible that the cognitive uncertainty and repeated behavioral checking evident in Obsessive Compulsive Disorder (OCD) is due to the existence of abnormalities in basic survival circuits, particularly those associated with ...
Plasticity of resting state brain networks in recovery from stress
Soares, JM; Sampaio, A; Marques, P; Ferreira, LM; Santos, NC; Marques, F; Palha, JA; Cerqueira, JJ; Sousa, NChronic stress has been widely reported to have deleterious impact in multiple biological systems. Specifically, structural and functional remodeling of several brain regions following prolonged stress exposure have been described; importantly, some of these changes are eventually reversible. Recently, we showed the impact of stress on resting state networks (RSNs), but nothing is known about the plasticity of ...
Stress Impact on Resting State Brain Networks
Soares, JM; Sampaio, A; Ferreira, LM; Santos, NC; Marques, PS; Marques, F; Palha, JA; Cerqueira, JJ; Sousa, NResting state brain networks (RSNs) are spatially distributed large-scale networks, evidenced by resting state functional magnetic resonance imaging (fMRI) studies. Importantly, RSNs are implicated in several relevant brain functions and present abnormal functional patterns in many neuropsychiatric disorders, for which stress exposure is an established risk factor. Yet, so far, little is known about the effect ...
Síndrome de Horner Pediátrica Associada à Ganglioneuroma: Relato de Caso
Sampaio, A; Paixão, A; Martins, M; Toscano, AOs autores apresentam um caso clínico, de uma criança, 5 anos, com miose do OE, ligeira ptose ipsilateral e heterocromia da íris. A duração dos sinais oftalmológicos é desconhecida. Procedeu- se ao teste farmacológico com Apraclonidina a 0,5% e houve dilatação do OE, com reversão da ptose. No OD não houve dilatação, confirmando-se o diagnóstico de Síndrome de Horner (SH). Foram realizados RNM do...
Uso do Voriconazol Oral no Tratamento da Endoftalmite Fúngica Endógena Bilate...
Sampaio, A; Pinto FerreiraOs autores descrevem um caso de endoftalmite fúngica bilateral, presumida por Candida, após cirurgia abdominal (hemicolectomia por divertículos) complicada por fístula enterocutanea e utilização de cateteres intravenosos. O doente foi submetido a tratamento com voriconazol oral, com bom resultado anatómico e funcional. São descritos os aspectos clínicos da endoftalmite fúngica, e a opção terapéutic...
Estudo Clínico da Utilização da Válvula de Ahmed no Glaucoma Refractário E...
Lisboa, M; Sampaio, A; Borges, B; Amaral, A; Domingues, I; Reina, M; Lisboa, JObjectivo: Avaliar os resultados clínicos nos doentes submetidos a implante de válvula de Ah- med no serviço de Oftalmologia do Centro Hospitalar de Lisboa Central, EPE, entre Janeiro de 2010 e Junho de 2012. Material e Métodos: Estudo retrospectivo em que 39 doentes (44 válvulas) foram incluídos. Os critérios de inclusão compreenderam o diagnóstico de glaucoma refractário à terapêutica máxi- ma to...