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Antifungal activity of palmatine against strains of Candida spp. resistant to a...
Campos, Rosana de Sousa; Silva, Cecília Rocha da; Andrade Neto, João Batista de; Sampaio, Letícia Serpa; Nascimento, Francisca Bruna Stefany Aires doThe incidence of fungal infections has increased and it is necessary to seek new antifungals that also act against resistant strains. Palmatine is a protoberberine alkaloid noteworthy for its various pharmacological properties, including antifungal properties. The objective of this study was to evaluate the activity of palmatine against Candida spp. strains resistant to azole in planktonic cells and biofilm, an...
In vitro evaluation of the curcumin against fluconazole-resistant strains of Ca...
Freitas, Daniel Domingues; Silva, Cecília Rocha da; Andrade Neto, João Batista de; Campos, Rosana de Sousa; Sampaio, Letícia SerpaThe isolates of Candida spp. and Cryptococcus neoformans were inhibited by curcumin, with different degrees of inhibition among species, with MICs ranging from 8-64 μg/mL. After exposure of the C. albicans strains to curcumin, it was observed a decrease in the number of viable cells and damage to cell membranes, the mitochondrial function of C. albicans cells appears to be affected after exposure to curcumin. O...
Avaliação in vitro da atividade do ibuprofeno frente a isolados de Candida spp....
Sampaio, Letícia SerpaIn recent years, there has been an increase in the incidence of opportunistic fungal infections. Candida species have been documented as an important cause of infections and related to high morbidity and mortality among hospitalized patients, increasing hospital costs and length of stay,configuring an important public health problem. Most fungal infections are associated with biofilm formation, which represents...
Screening of antimicrobial metabolite yeast isolates derived biome Ceará agains...
Andrade Neto, João Batista de; Silva, Cecília R. da; Nascimento, Francisca Bruna Stefany Aires do; Sampaio, Letícia Serpa; Silva, Anderson R. daAntimicrobials benefited the history of medicine by revolutionizing the treatment of infectious diseases. However, its consequent and continuous use has led to the emergence of microorganisms which once were considered safe, but have become feared as potentially lethal pathogens (Bowler et al., 2012). Staphylococcus aureus infections are highlighted for being a major cause of systemic infections, and for being ...
Berberine antifungal activity in fluconazole-resistant pathogenic yeasts : acti...
Silva, Anderson Ramos da; Andrade Neto, João Batista de; Silva, Cecília Rocha da; Campos, Rosana de Sousa; Silva, Rose Anny CostaThe incidence of fungal infections and, in particular, the incidence of fungal antibiotic resistance, which is associated with bio- film formation, have significantly increased, contributing to morbidity and mortality. Thus, new therapeutic strategies need to be developed. In this context, natural products have emerged as a major source of possible antifungal agents. Berberine is a pro- toberberine-type isoquin...
Evaluation of synergistic effect of kaurenoic acid derivatives with fluconazole...
Andrade Neto, João Batista de; Silva, Cecília Rocha da; Campos, Rosana de Sousa; Nascimento, Francisca Bruna Stefany Aires do; Sampaio, Letícia SerpaCandida species are the fourth most common cause of nosocomial bloodstream infections in the United States and the fifth to tenth most common causative pathogen in European studies Although C. albicans remains the most common fungal isolate recovered from blood, recent reports indicate a trend towards an increasing prevalence of infections caused by species of Candida other than C. albicans which are associated...
Synergistic effect of the flavonoid catechin, quercetin, or epigallocatechin ga...
Silva, Cecília Rocha da; Andrade Neto, João Batista de; Campos, Rosana de Sousa; Figueiredo, Narjara Silvestre; Sampaio, Letícia SerpaFlavonoids are a class of phenolic compounds commonly found in fruits, vegetables, grains, flowers, tea, and wine. They differ in their chemical structures and characteristics. Such compounds show various biological functions and have antioxidant, antimicrobial, anti-inflammatory, and antiapoptotic properties. The aim of this study was to evaluate the in vitro interactions of flavonoids with fluconazole against...