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Iridium–Iron Diatomic Active Sites for Efficient Bifunctional Oxygen Electrocat...

Yu, Zhipeng; Si, Chaowei; LaGrow, Alec P.; Tai, Zhixin; Caliebe, Wolfgang A.; Tayal, Akhil; Sampaio, Maria J.; Sousa, Juliana P. S.; Amorim, Isilda

Diatomic catalysts, particularly those with heteronuclear active sites, have recently attracted considerable attention for their advantages over single-atom catalysts in reactions involving multielectron transfers. Herein, we report bimetallic iridium−iron diatomic catalysts (IrFe−N−C) derived from metal−organic frameworks in a facile wet chemical synthesis followed by postpyrolysis. We use various advanced cha...


Enhanced biocatalytic sustainability of laccase by immobilization on functional...

Costa, João B.; Lima, Maria J.; Sampaio, Maria J.; Neves, Márcia C.; Faria, Joaquim L.; Morales-Torres, Sergio; Tavares, Ana P. M.; Silva, Cláudia G.

Chemically functionalized multi-walled carbon nanotubes (CNTs) are used as carriers for laccase immobilization. In this work, CNTs were modified using different approaches with a combination of methods involving hydrothermal oxidation with nitric acid, treatment with 3-aminopropyltriethoxysilane, glutaraldehyde, N-ethyl-N-(3-(dimethylamino)-propyl) carbodiimide hydrochloride and N-hydroxysuccinimide. The enzyme...


Using carbon nanotubes for antileukemic drugs purification

Nunes, João C. F.; Cristóvão, Raquel O.; Barros, Maria A.; Almeida, Mafalda R.; Faria, Joaquim L.; Sampaio, Maria J.; Freire, Mara G.

Nowadays, the average life expectancy is progressively increasing. Nevertheless, there are still several fatal diseases generally associated with aging, such as cancer, heart and neurological diseases. Biopharmaceuticals as nucleic-acid-based products, antibodies and recombinant proteins and enzymes are applied in order to overcome these age-related diseases. L-asparaginase (LA) is one of the most broadly used ...


Tailoring carbon nanotubes surface chemistry for the purification of antileukem...

Barros, Maria A.; Almeida, Mafalda R.; Faria, Joaquim L.; Sampaio, Maria J.; Tavares, Ana P. M.; Silva, Cláudia G.

Biopharmaceuticals have been used to overcome fatal diseases related with aging. L-aspariginase (LA), in particular, has shown evidences of being efficient for leukemia therapy. The LA production and purification require several steps increasing the cost of the process. In this work, functionalized carbon nanotubes (CNTs) were studied as a cost-effective support to purify LA. It was shown that CNTs have strong ...


An application of the extended global SO(3) × SO(3) × U(1) symmetry of the Hubb...

Carmelo, José Manuel Pereira; Sampaio, Maria J.

In this paper we review recent results on the preliminary applications of the new-found extended global SO(3) × SO(3) × U(1) symmetry of the Hubbard model on a bipartite lattice. Our results refer to the particular case of the bipartite square lattice. Specifically, we review a general description for such a model with nearest-neighbor transfer integral <em>t</em> and on-site repulsion <em>U</em> on a square la...


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Sampaio, Maria J.; Fiolhais, Carlos


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