4 documents found, page 1 of 1
M3L: exploring synergies between metabolic modelling and machine learning for s...
Sampaio, Marta Sofia CostaVitis vinifera (videira) é uma das principais árvores de fruto do mundo, sendo amplamente cultivada e comercializada, principalmente para produção de vinho. Como a qualidade do vinho está diretamente relacionada com a qualidade da uva, o estudo do metabolismo da videira é importante para esclarecer os processos subjacentes à composição da uva. Modelos metabólicos à escala genómica têm sido usados no estudo do m...
Towards a multivariate analysis of genome-scale metabolic models derived from t...
Oliveira, Alexandre Rafael Machado; Cunha, Emanuel Rodrigues; Cruz, Fernando João Pereira da; Ribeiro, João Manuel Capela AraújoGenome-Scale metabolic models (GEMs) are a relevant tool in systems biology for in silico strain optimisation and drug discovery. An easier way to reconstruct a model is to use available GEMs as templates to create the initial draft, which can be curated up until a simulation-ready model is obtained. This approach is implemented in merlin's BiGG Integration Tool, which reconstructs models from existing GEMs pre...
PhagePromoter: phage promoters online analysis tool
Sampaio, Marta Sofia CostaIn the last decades, the emergence and evolution of the Next Generation Sequence technologies have revolutionised genomic research, leading to an exponential increase in the number of sequenced genomes. Many of the sequenced genomes belong to bacteriophages (phages), mostly due to their therapeutic potential against bacterial infections. This abundance of genomic data demands the creation of user-friendly bioin...
Endolysin binding domain is highly conserved in staphylococcal phage genomes
Oliveira, Hugo Alexandre Mendes; Sampaio, Marta Sofia Costa; Melo, Luís Daniel Rodrigues; Dias, Oscar; Azeredo, JoanaBacteriophages are the most predominant and diverse entities in any ecosystem, mostly driven by constant predatorprey evolution dynamics and horizontal gene transfer. Phage population remains an untapped and uncharacterized source of genetic diversity with highly mosaic genomes and no universal genes. To better understand the genetic diversity and the evolutionary relationships of staphylococci infecting phages...