3 documents found, page 1 of 1
The recombinant plant Bauhinia bauhinioides elastase inhibitor reduces rat thro...
Oliveira, Cleide; Valois, Mayara Vioto; Ottaiano, Tatiana Fontes; Miranda, Antonio; Hansen, Daiane; Sampaio, Misako Uemura; Oliva, Maria Luiza VilelaMade available in DSpace on 2022-04-29T08:30:14Z (GMT). No. of bitstreams: 0 Previous issue date: 2021-12-01; The anti-inflammatory effects of the plant protease inhibitor BbCI (Bauhinia bauhinioides cruzipain inhibitor), which blocks elastase, cathepsin G, and L, and proteinase 3 has been demonstrated. Here, we investigated the recombinant rBbCI-His(6) (containing a histidine tail) in an experimental venous th...
Effects of compounds from passiflora edulis Sims f. flavicarpa juice on blood c...
Sato, Ana Claudia; Andrade, Sonia A.; Brito, Marlon V.; Miranda, Antonio; Sampaio, Misako Uemura; De Abreu Maffei, Francisco Humberto [UNESP]Made available in DSpace on 2022-04-29T02:56:41Z (GMT). No. of bitstreams: 0 Previous issue date: 2012-05-01; Passion fruit (Passiflora edulis Sims f. flavicarpa) is popularly known for its sedative and calming properties and is consumed as a fresh fruit or as a juice. The clinical observation of blood incoagulability associated with excessive consumption of passion fruit juice, in a patient treated with warfar...
Crystal structure of a novel cysteinless plant Kunitz-type protease inhibitor
Hansen, Daiane; Macedo-Ribeiro, Sandra; Veríssimo, Paula; Yoo Im, Sonia; Sampaio, Misako Uemura; Oliva, Maria Luiza VilelaBauhinia bauhinioides Cruzipain Inhibitor (BbCI) is a cysteine protease inhibitor highly homologous to plant Kunitz-type inhibitors. However, in contrast to classical Kunitz family inhibitors it lacks cysteine residues and therefore disulfide bridges. BbCI is also distinct in the ability to inactivate enzymes belonging to two different classes, cysteine and serine proteases. Besides inhibiting the cysteine prot...