17 documents found, page 1 of 2
Chicken feather keratin peptides for the control of keratinocyte migration
Botelho, CM; Ferreira-Santos, P; Toubarro, D; Dinis, H; Osorio, H; Costa-Barbosa, A; Sampaio, P; Simões, N; Teixeira, JAFAO estimates that in 2030 the poultry meat production could reach 120 million tons, which is a challenge in terms of waste management. Feathers are mainly composed of keratin, an important biomaterial. Using feathers as a source of keratin will minimize the waste generated, while contributing to supply an important material for several industries, such as pharmaceutical and biomedical. The peptides were extrac...
Forecasting COVID-19 Severity by Intelligent Optical Fingerprinting of Blood Sa...
Faria, SP; Carpinteiro, C; Pinto, V; Rodrigues, SM; Alves, J; Marques, F; Lourenço, M; Santos, PH; Ramos, A; Cardoso, MJ; Guimarães, JT; Rocha, SForecasting COVID-19 disease severity is key to supporting clinical decision making and assisting resource allocation, particularly in intensive care units (ICUs). Here, we investigated the utility of time- and frequency-related features of the backscattered signal of serum patient samples to predict COVID-19 disease severity immediately after diagnosis. ICU admission was the primary outcome used to define dise...
The membrane periodic skeleton is an actomyosin network that regulates axonal d...
Costa, AR; Sousa, SC; Pinto-Costa, R; Mateus, JC; Lopes, CDF; Costa, AC; Rosa, D; Machado, D; Pajuelo, L; Wang, X; Zhou, FQ; Pereira, AJ; Sampaio, PNeurons have a membrane periodic skeleton (MPS) composed of actin rings interconnected by spectrin. Here, combining chemical and genetic gain-and loss-of-function assays, we show that in rat hippocampal neurons the MPS is an actomyosin network that controls axonal expansion and contraction. Using super-resolution microscopy, we analyzed the localization of axonal non-muscle myosin II (NMII). We show that active...
Author Correction: iLoF: An intelligent Lab on Fiber Approach for Human Cancer ...
Paiva, JS; Jorge, PAS; Ribeiro, RSR; Balmaña, M; Campos, D; Mereiter, S; Jin, C; Karlsson, NG; Sampaio, P; Reis, CA; Cunha, JPSAn amendment to this paper has been published and can be accessed via a link at the top of the paper.
iLoF: An intelligent Lab on Fiber Approach for Human Cancer Single-Cell Type Id...
Paiva, JS; Jorge, PAS; Ribeiro, RSR; Balmaña, M; Campos, D; Mereiter, S; Jin, C; Karlsson, NG; Sampaio, P; Reis, CA; Cunha, JPSWith the advent of personalized medicine, there is a movement to develop “smaller” and “smarter” microdevices that are able to distinguish similar cancer subtypes. Tumor cells display major differences when compared to their natural counterparts, due to alterations in fundamental cellular processes such as glycosylation. Glycans are involved in tumor cell biology and they have been considered to be suitable can...
Optical fiber-based sensing method for nanoparticle detection through supervise...
Paiva, JS; Jorge, PAS; Ribeiro, RSR; Sampaio, P; Rosa, CC; Cunha, JPSBackground: In view of the growing importance of nanotechnologies, the detection/identification of nanoparticles type has been considered of utmost importance. Although the characterization of synthetic/organic nanoparticles is currently considered a priority (eg, drug delivery devices, nanotextiles, theranostic nanoparticles), there are many examples of “naturally” generated nanostructures - for example, extra...
Supply chain management practices and firms' operational performance
Truong, HQ; Sameiro, M; Fernandes, AC; Sampaio, P; Duong, BAT; Vilhenac, EPurpose: the purpose of this paper is to provide an empirical evidence about the relationship between practices of supply chain management (SCM) and operational performance (OP). Design/methodology/approach: based on a comprehensive literature review, a set of SCM practices has been identified and selected to develop a conceptual model as well as to establish their relationship to companies’ OP. The measurement...
Microfluidic-based platform to mimic the in vivo peripheral administration of n...
Lopes, C; Gomes, C; Neto, E; Sampaio, P; Aguiar, P; Pêgo, APAim: Propose a nanoparticle for neuron-targeted retrograde gene delivery and describe a microfluidic-based culture system to provide insight into vector performance and safety. Methods: Using compartmentalized neuron cultures we dissected nanoparticle bioactivity upon delivery taking advantage of (quantitative) bioimaging tools. Results: Targeted and nontargeted nanoparticles were internalized at axon terminals...
The actin-binding protein α-adducin is required for maintaining axon diameter
Leite, SC; Sampaio, P; Sousa, VF; Nogueira-Rodrigues, J; Pinto-Costa, R; Peters, LL; Brites, P; Sousa, MMThe actin-binding protein adducin was recently identified as a component of the neuronal subcortical cytoskeleton. Here, we analyzed mice lacking adducin to uncover the function of this protein in actin rings. a-adducin knockout mice presented progressive axon enlargement in the spinal cord and optic and sciatic nerves, followed by axon degeneration and loss. Using stimulated emission depletion super-resolution...
An extensive structural model of supply chain quality management and firm perfo...
Quang, HT; Sampaio, P; Carvalho, MS; Fernandes, AC; Binh An, DT; Vilhenac, EPurpose – The purpose of this paper is to explore the concept of supply chain quality management (SCQM) and to propose a research model that considers the impact of SCQM practices on firm performance. Design/methodology/approach – Based on a comprehensive literature review, SCQM most relevant practices were analyzed and selected. These practices were categorized into four dimensions: upstream (supplier assessme...