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Topical antinociceptive effect of vanillosmopsis arborea baker on acute corneal...

Leite, Laura Hévila Inocêncio; Leite, Gerlânia de Oliveira; Coutinho, Thales Silva; Sousa, Severino Denício Gonçalves de; Sampaio, Renata Souza

This study aimed to assess the possible topical antinociceptive activity of Vanillosmopsis arborea Baker essential oil (EOVA) and to clarify the underlying mechanism, using the acute model of chemical (eye wiping) nociception in mice. EOVA (25 to 200mg/kg; p.o. and topical) evidenced significant antinociception against chemogenic pain in the test model of formalin-induced neuroinflammatory pain. Local applicati...

Date: 2014   |   Origin: Oasisbr
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