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Successful treatment of diffuse cutaneous leishmaniasis caused by Leishmania am...
Sampaio,Raimunda Nonata Ribeiro; Ferreira,Marina Freitas; Martins,Sofia Sales; Motta,Jorgeth de Oliveira Carneiro daAbstract Diffuse cutaneous leishmaniasis is a rare universal disease associated with an inadequate host cell immune response, caused by different species: infantum, aethiopica, major, mexicana, and others, which presents the challenge of a poor therapeutic response. In Brazil, it is caused by L. amazonensis. A case confirmed by histopathology with an abundance of vacuolated macrophages full of amastigotes and l...
The accuracy of the Montenegro skin test for leishmaniasis in PCR-negative pati...
Pinheiro,Ana Bárbara Sapienza; Kurizky,Patricia Shu; Ferreira,Marina de Freitas; Mota,Marco Antonio de Souza; Ribeiro,Jaqueline SantosAbstract INTRODUCTION: As highly specific molecular biology-based techniques may not be sensitive enough for the diagnosis of American tegumentary leishmaniasis (ATL), clinicians frequently rely on immunological tests before treatment initiation. Hence, the correct combination of diagnostic tests is imperative for ATL diagnosis. We aimed to evaluate the accuracy of the Montenegro (Leishmanin) skin test (MST) in...
The interference of polypharmacy and the importance of clinical pharmacy advice...
Cerqueira,Selma Regina Penha Silva; Santos,Lais Sevilha dos; Morelo,Elaine Faria; Santos Júnior,Agenor de Castro Moreira dosAbstract INTRODUCTION: Although supervised doses are essential for reducing leprosy treatment failure, the impact of specific drug interactions has rarely been assessed. This study aimed to estimate the risk of leprosy treatment suspension in patients receiving polypharmacy. METHODS We performed this case-control study in which the primary outcome was defined as the need to discontinue multibacillary leprosy tr...
A randomized, open-label clinical trial comparing the long-term effects of milt...
Sampaio,Raimunda Nonata Ribeiro; Silva,Juliana Saboia Fontenele e; Paula,Carmen Dea Ribeiro de; Porto,Cláudia; Motta,Jorgeth de Oliveira Carneiro daAbstract INTRODUCTION: The treatment of mucosal leishmaniasis (ML) is difficult due to the toxicity and route of administration of standard drugs. Miltefosine is an oral agent used for leishmaniasis treatment; however, no data exist regarding its use for ML in Brazil. In this study, we aimed to evaluate the efficacy of miltefosine for ML treatment compared to that of pentavalent antimonial in a pilot study. MET...
American cutaneous leishmaniasis triggered by electrocoagulation
Martins,Sofia Sales; Santos,Adriana de Oliveira; Lima,Beatriz Dolabela; Gomes,Ciro Martins; Sampaio,Raimunda Nonata RibeiroAbstract Cutaneous leishmaniasis is usually transmitted by infected phlebotomine sand fly bites that initiate local cutaneous lesions. Few reports in the literature describe other modes of transmission. We report a case of a previously healthy 59-year-old woman who underwent electrocoagulation to remove seborrheic keratosis confirmed by dermatoscopy. Three months later, a skin fragment tested positive for Leish...
Field validation of a Leishmania (Leishmania) mexicana exo-antigens ELISA for d...
Soares,Killarney Ataide; Urdapilleta,Ada Amália Ayala; Santos,Gilcilene Maria dos; Carneiro,Andréa Lisboa; Gomes,Ciro Martins; Roselino,Ana MariaBackground: Several tests are performed to obtain better accuracy when diagnosing American tegumentary leishmaniasis (ATL). It is believed that antigens released via secretion, excretion and metabolism are more specific than are antigens released by the lysis of Leishmaniaparasites. Such antigens are known as exo-antigens (exo-Ag) and are formed from products released by cultured parasites in a way that is simi...
Complementary exams in the diagnosis of american tegumentary leishmaniasis
Gomes,Ciro Martins; de Paula,Natália Aparecida; Morais,Orlando Oliveira de; Soares,Killarney Ataíde; Roselino,Ana Maria; Sampaio,Raimunda Nonata RibeiroThe diagnosis of American Tegumentary Leishmaniasis is a difficult but essential task when considering the high toxicity profile of the drugs available. Since the discovery of its etiologic agent, numerous diagnostic tests have been developed. None of the tests available today can be considered as the gold standard, since they do not add enough accuracy for the disease detection. Good epidemiological and clinic...
Recurrent cutaneous leishmaniasis
Gomes,Ciro Martins; Damasco,Fabiana dos Santos; Morais,Orlando Oliveira de; Paula,Carmen Dea Ribeiro de; Sampaio,Raimunda Nonata RibeiroWe present a case of an 18-year-old male patient who, after two years of inappropriate treatment for cutaneous leishmaniasis, began to show nodules arising at the edges of the former healing scar. He was immune competent and denied any trauma. The diagnosis of recurrent cutaneous leishmaniasis was made following positive culture of aspirate samples. The patient was treated with N-methylglucamine associated with...
Periungual leishmaniasis
Gomes,Ciro Martins; Morais,Orlando Oliveira de; Leite,Anglya Samara Silva; Soares,Killarney Ataíde; Motta,Jorgeth de Oliveira Carneiro daThe vast majority of cases of cutaneous leishmaniasis are represented by limb injuries. A female patient, white, presented an ulcer with infiltrated borders located on the fourth finger of the left hand following occupational exposure in an area of native forest. Diagnosis of cutaneous leishmaniasis caused by Leishmania of the subgenus Viannia was confirmed. The patient failed to respond to treatment with antim...
O uso da associação azitromicina e N-metil glucamina no tratamento da leishmani...
Sampaio,Raimunda Nonata Ribeiro; Lucas,Íris Campos; Costa Filho,Arnoldo Velloso daFUNDAMENTOS: O tratamento de primeira escolha da leishmaniose tegumentar americana é a N-metil-glucamina que tem alta toxicidade, exige administração parenteral e nem sempre cura. A azitromicina mostrou ação in vitro e resultado contraditório na doença humana. OBJETIVO: Verificar se a associação N-metil-glucamina+azitromicina é mais eficaz do que N-metil-glucamina no tratamento da leishmaniose experimental. MÉT...