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The role of biotics as a therapeutic strategy for oral mucositis - a systematic...

Frey-Furtado, Leonor; Magalhães, Inês; Azevedo, Maria João; Sampaio-Maia, Benedita

Objectives: Oral mucositis (OM) is an acute and highly prevalent side effect of cancer treatments. Currently, there is no effective strategy for its prevention or treatment. This systematic review aimed to assess the effectiveness of biotics used as a therapeutic strategy for the management of OM. Materials and Methods: The PRISMA checklist was followed and PubMed, Web of Science, and Scopus were screened for c...


Forensic microbiology and geographical location: a systematic review

Moitas, Bruna; Caldas, Inês Morais; Sampaio-Maia, Benedita

Establishing geographical location is a crucial aspect of forensic sciences, distinguishing between primary and secondary crime scenes, linking an individual to a crime scene, or detecting sources of disease. Microorganisms can be used as geolocation indicators since microbial communities vary according to climatic factors (e.g. temperature, humidity, soil properties, altitude). Therefore, this systematic revie...


Potential pathogenic and opportunistic oral bacteria in early life: the role of...

Fernandes, Mariana; Azevedo, Maria João; Campos, Carla; Ferreira, Ana Filipa; Azevedo, Álvaro; Falcão-Pires, Inês; Zaura, Egija; Ramalho, Carla

In early life, maternal factors are of the utmost relevance for oral microbiome acquisition and maturation. Therefore, our study explored the impact of maternal factors, such as saliva and breastmilk colonization, cardiovascular risk factors (CRF), type of delivery, oral health, and caregiving habits on the prevalence of potential pathogenic and opportunistic oral bacteria in early life. A total of 26 healthy m...


Sample preparation and chromatographic methods for the determination of protein...

Fernandes, Sara R.; Meireles, Andreia N.; Marques, Sara S.; Silva, Luís; Barreiros, Luisa; Sampaio-Maia, Benedita; Miro, Manuel; Segundo, Marcela A.

Protein-bound uremic retention solutes, such as indole-3-acetic acid, indoxyl sulfate, p-cresol and p-cresol sulfate, are associated with the development of several pathologies, namely renal, cardiovascular, and bone toxicities, due to their potential accumulation in the human body, thus requiring analytical methods for monitoring and evaluation. The present review addresses conventional and advanced sample tre...


Total analysis system for the determination of uremic toxins in human plasma ba...

Fernandes, Sara; Barreiros, Luísa; Sampaio-Maia, Benedita; Miró, Manuel; Segundo, Marcela A.

Indoxyl sulfate (INDS) and p-cresol sulfate (pCS) are two of the most relevant uremic toxins that are recognized to have an essential role in chronic kidney disease (CKD) progression and associated cardiovascular risk. Thus, it is crucial to accurately assess their circulating levels in the body. Aiming at establishing an analytical strategy for quantification of INDS and pCS in human plasma, an automatic on-li...


Unveiling the relevance of the oral cavity as a staphylococcus aureus colonizat...

Campos, Joana; Faria Pires, Mariana; Sousa, Marta; Campos, Carla; Fernandes Ferreira Alves da Costa, Carolina; Sampaio-Maia, Benedita

Staphylococcus aureus is both a human commensal and a pathogen, that causes serious nosocomial and community-acquired infections. Despite nostrils being considered its preferred host habitat, the oral cavity has been demonstrated to be an ideal starting point for auto-infection and transmission. The antibiotic resistance assessment of S. aureus is a priority and is often reported in clinical settings. This stud...


Vertical transmission and antifungal susceptibility profile of yeast isolates f...

Azevedo, Maria João; Araújo, Ricardo; Campos, Joana; Campos, Carla; Ferreira, Ana Filipa; Falcão-Pires, Inês; Ramalho, Carla; Zaura, Egija

Yeast acquisition begins at birth; however, the contribution of the mother on yeast trans mission to the offspring and associated resistance is yet to be clarified. The aim of this study was to explore the vertical transmission of yeasts and their antifungal susceptibility profile in early life. Oral, fecal, and breastmilk samples were collected from 73 mother–child pairs four to twelve weeks after delivery and...


What is the evidence for dietary and nutritional interventions in ADHD?

Pinto, Sofia; Correia-de-Sá, Teresa; Sampaio-Maia, Benedita; Vasconcelos, Carla; Moreira, Pedro; Ferreira-Gomes, Joana


What is the evidence for dietary and nutritional interventions in ADHD?

Pinto, Sofia; Correia-de-Sá, Teresa; Sampaio-Maia, Benedita; Vasconcelos, Carla; Moreira, Pedro; Ferreira-Gomes, Joana


Pseudomonadota in the oral cavity: a glimpse into the environment-human nexus

Leão, Inês; Carvalho, Teresa Bento de; Henriques, Valentina; Ferreira, Catarina; Sampaio-Maia, Benedita; Manaia, Célia M.

The phylum Pseudomonadota is amongst the most represented in the environment, with a comparatively lower prevalence in the human oral cavity. The ubiquity of Pseudomonadota and the fact that the oral cavity is the most likely entry portal of bacteria from external sources underlie the need to better understand its occurrence in the interface environment-humans. Yet, the relevance oral Pseudomonadota is largely ...


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