2 documents found, page 1 of 1
Functional genetic variants in atg10 are associated with acute myeloid leukemia
Castro, I; Sampaio-Marques, B; Areias, AC; Sousa, H; Fernandes, Â; Sanchez-Maldonado, JM; Cunha, C; Carvalho, A; Sainz, J; Ludovico, PAcute myeloid leukemia (AML) is the most common acute leukemia, characterized by a heterogeneous genetic landscape contributing, among others, to the occurrence of metabolic repro-gramming. Autophagy, a key player on metabolism, plays an essential role in AML. Here, we examined the association of three potentially functional genetic polymorphisms in the ATG10 gene, central for the autophagosome formation. We sc...
AMPK in Pathogens
Mesquita, I; Moreira, D; Sampaio-Marques, B; Laforge, M; Cordeiro-da-Silva, A; Ludovico, P; Estaquier, J; Silvestre, RDuring host-pathogen interactions, a complex web of events is crucial for the outcome of infection. Pathogen recognition triggers powerful cellular signaling events that is translated into the induction and maintenance of innate and adaptive host immunity against infection. In opposition, pathogens employ active mechanisms to manipulate host cell regulatory pathways toward their proliferation and survival. Amon...