2 documents found, page 1 of 1
Prevascularized spongy-like hydrogels maintain their angiogenic potential after...
Ribeiro, Sara Cristina Freitas; Moreira, H.; da Silva, Lucília Pereira; Noro, Jennifer Martins; Sampaio-Marques, B.; Ludovico, Paula; Jarnalo, M.The chronic shortage of organs and tissues for transplantation represents a dramatic burden on healthcare systems worldwide. Tissue engineering offers a potential solution to address these shortages, but several challenges remain, with prevascularization being a critical factor for in vivo survival and integration of tissue engineering products. Concurrently, a different challenge hindering the clinical impleme...
Lipocalin-2 regulates adult neurogenesis and contextual discriminative behaviours
Ferreira, A. C.; Santos, T.; Sampaio-Marques, B.; Novais, Ashley Cruz; Mesquita, S. D.; Ludovico, Paula; Bernardino, L.; Correia-Neves, M; Sousa, NunoIn the adult mammalian brain, newborn granule cells are continuously integrated into hippocampal circuits, and the fine-tuning of this process is important for hippocampal function. Thus, the identification of factors that control adult neural stem cells (NSCs) maintenance, differentiation and integration is essential. Here we show that the deletion of the iron trafficking protein lipocalin-2 (LCN2) induces def...