2 documents found, page 1 of 1
Establishing a Link between Endothelial Cell Metabolism and Vascular Behaviour ...
Silva, Carolina; Sampaio-Pinto, Vasco; Andrade, Sara; Rodrigues, Ilda; Costa, Raquel; Guerreiro, Susana; Carvalho, Eugenia; Pinto-do-Ó, PerpétuaVascular complications contribute significantly to the extensive morbidity and mortality rates observed in people with diabetes. Despite well known that the diabetic kidney and heart exhibit imbalanced angiogenesis, the mechanisms implicated in this angiogenic paradox remain unknown. In this study, we examined the angiogenic and metabolic gene expression profile (GEP) of endothelial cells (ECs) isolated from a ...
Neonatal Apex Resection Triggers Cardiomyocyte Proliferation, Neovascularizatio...
Sampaio-Pinto, Vasco; Rodrigues, Sílvia C.; Laundos, Tiago L.; Silva, Elsa D.; Vasques-Nóvoa, Francisco; Silva, Ana C.; Cerqueira, Rui J.So far, opposing outcomes have been reported following neonatal apex resection in mice, questioning the validity of this injury model to investigate regenerative mechanisms. We performed a systematic evaluation, up to 180 days after surgery, of the pathophysiological events activated upon apex resection. In response to cardiac injury, we observed increased cardiomyocyte proliferation in remote and apex regions,...