2 documents found, page 1 of 1
Linear Peptide Analogues from Jatropha’s Orbitides Promote Migration of Human N...
Ramalho,Suelem D.; Pinto,Meri Emili F.; Andricopulo,Renata K.; Sanches,Paulo R. S.; Silveira,Edilberto R.; Cilli,Eduardo M.; Andricopulo,Adriano D.Orbitides are a class of small naturally occurring cyclic peptides with structural and functional diversities. Their chemical properties make this class feasible to be obtained by solid phase peptide synthesis (SPPS). Therefore, this synthetic accessibility enables useful application and facilitates the identification of analogues, bioactivity studies, and thus, enables them to be applied to obtain peptide libr...
The Octahydroindene Carboxyl Substructure from Dihydrobetulinic Acid is Essenti...
Rocha,Camila A.; Sanches,Paulo R. S.; Marchetto,Reinaldo; Zottis,AdersonThe dihydrobetulinic acid is a known competitive inhibitor of topoisomerase IB from Leishmania donovani, a validated target for developing new antileishmanial drugs. However, its binding mode and interaction pocket have not been established yet. We combined docking and molecular dynamics simulations to identify the most probable binding pocket. Our best model strongly suggests a cavity involving the residues ar...