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Validity of a Clinical Scale in Predicting the Failure of Non-Invasive Ventilat...

Carrillo, A; Lopez, A; Carrillo, L; Caldeira, V; Guia, M; Alonso, N; Renedo, A; Quintana, M; Sanchez, J; Esquinas, A

Introduction: The HACOR scale is a clinical score that can predict early failure of NIV in hypoxemic acute respiratory failure (ARF) The aim of this study is to analyze the validity of the HACOR scale. Methods: A retrospective study of a cohort of over 2749 episodes on 2711 consecutive patients requiring NIV for hypoxemic ARF in a polyvalent intensive care unit. The scale was measured before starting NIV and at...


3D Cellular Architecture Affects MicroRNA and Protein Cargo of Extracellular Ve...

Rocha, S; Carvalho, J; Oliveira, P; Voglstaetter, M; Schvartz, D; Thomsen, A; Walter, N; Khanduri, R; Sanchez, J; Keller, A; Oliveira, C; Nazarenko, I

The success of malignant tumors is conditioned by the intercellular communication between tumor cells and their microenvironment, with extracellular vesicles (EVs) acting as main mediators. While the value of 3D conditions to study tumor cells is well established, the impact of cellular architecture on EV content and function is not investigated yet. Here, a recently developed 3D cell culture microwell array is...


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