30 documents found, page 1 of 3
Physicochemical and biopharmaceutical aspects influencing skin permeation and r...
Souto, Eliana; Fangueiro, Joana F.; Fernandes, Ana R.; Cano, Amanda; Sanchez-Lopez, Elena; Garcia, Maria L.; Severino, Patrícia; Paganelli, Maria O.The skin is a complex and multifunctional organ, in which the static versus dynamic balance is responsible for its constant adaptation to variations in the external environment that is continuously exposed. One of the most important functions of the skin is its ability to act as a protective barrier, against the entry of foreign substances and against the excessive loss of endogenous material. Human skin impose...
Correction: Diniz et al. Silver Nanoparticles-Composing Alginate/Gelatine Hydro...
Diniz, Flavia Resende; Maia, Romerito Cesar A. P.; de Andrade, Lucas Rannier M.; Andrade, Luciana Nalone; Vinicius Chaud, MarcoIn the original publication, there was a mistake in Figure 6 as published [...]
Physicochemical and biopharmaceutical aspects influencing skin permeation and r...
Souto, Eliana B.; Fangueiro, Joana F.; Fernandes, Ana R.; Cano, Amanda; Sanchez-Lopez, Elena; Garcia, Maria L.; Severino, Patrícia; Paganelli, Maria O.The skin is a complex and multifunctional organ, in which the static versus dynamic balance is responsible for its constant adaptation to variations in the external environment that is continuously exposed. One of the most important functions of the skin is its ability to act as a protective barrier, against the entry of foreign substances and against the excessive loss of endogenous material. Human skin impose...
Permeability, anti-inflammatory and anti-VEGF profiles of steroidal-loaded cati...
Fernandes, Ana R.; Santos, Tiago dos; Granja, Pedro L.; Sanchez-Lopez, Elena; Garcia, Maria L.; Silva, Amelia M.; Souto, Eliana B.Age-related macular degeneration (AMD) is defined as a degenerative, progressive and multifactorial disorder that affects the macula with a complex etiology. The retinal pigment epithelium is a monolayer of cells that has the function to separate the surface of the choroid from the neural retina that is involved in the signal transduction leading to vision. The blood-aqueous barrier and the blood retinal barrie...
Exudative versus nonexudative age-related macular degeneration: Physiopathology...
Fernandes, Ana Rita; Zielinska, Aleksandra; Sanchez-Lopez, Elena; dos Santos, Tiago; Garcia, Maria Luisa; Silva, Amelia M.; Karczewski, JacekAge-related macular degeneration (AMD) is an eye disease typically associated with the aging and can be classified into two types—namely, the exudative and the nonexudative AMD. Currently available treatments for exudative AMD use intravitreal injections, which are associated with high risk of infection that can lead to endophthalmitis, while no successful treatments yet exist for the nonexudative form of AMD. ...
Mono- and Dicationic DABCO/Quinuclidine Composed Nanomaterials for the Loading ...
Fernandes, Ana R.; Sanchez-Lopez, Elena; Santini, Antonello; Santos, Tiago dos; Garcia, Maria L.; Silva, Amélia Maria Lopes Dias da; Souto, Eliana B.Oil-in-water nanoemulsions (NEs) are considered a suitable nanotechnological approach to improve the eye-related bioavailability of lipophilic drugs. The potential of cationic NEs is prominent due to the electrostatic interaction that occurs between the positively charged droplets with the negatively charged mucins present in the tear film. This interaction offers prolonged NEs residence at the ocular surface, ...
Lipid-Polymeric Films: Composition, Production and Applications in Wound Healin...
Souto, Eliana B.; Yoshida, Cristiana M. P.; Leonardi, Gislaine R.; Cano, Amanda; Sanchez-Lopez, Elena; Zielińska, Aleksandra; Viseras, CésarThe use of lipids in the composition of polymeric-based films for topical administration of bioactive ingredients is a recent research topic; while few products are commercially available, films containing lipids represent a strategic area for the development of new products. Some lipids are usually used in polymeric-based film formulations due to their plasticizing action, with a view to improving the mechanic...
Mono- and dicationic DABCO/Quinuclidine composed nanomaterials for the loading ...
Fernandes, Ana R.; Sanchez-Lopez, Elena; Santini, Antonello; Santos, Tiago dos; Garcia, Maria L.; Silva, Amélia M.; Souto, Eliana B.Oil-in-water nanoemulsions (NEs) are considered a suitable nanotechnological approach to improve the eye-related bioavailability of lipophilic drugs. The potential of cationic NEs is prominent due to the electrostatic interaction that occurs between the positively charged droplets with the negatively charged mucins present in the tear film. This interaction offers prolonged NEs residence at the ocular surface, ...
Lipid nanocarriers for hyperproliferative skin diseases
Souto, Eliana B.; Souza, Ana L. R. de; Santos, Fernanda K. dos; Sanchez-Lopez, Elena; Cano, Amanda; Zielinska, Aleksandra; Staszewski, RafalHyperproliferative skin diseases (HSD) are a group of diseases that include cancers, pre-cancerous lesions and diseases of unknown etiology that present different skin manifestations in terms of the degree and distribution of the injuries. Anti-proliferative agents used to treat these diseases are so diverse, including 5-aminolevulinic acid, 5-fluorouracil, imiquimod, methotrexate, paclitaxel, podophyllotoxin, ...
Silver nanoparticles obtained from Brazilian pepper extracts with synergistic a...
Oliveira, Daniele M. de; Menezes, Diego B.; Andrade, Lucas R.; Lima, Felipe da C.; Hollanda, Luciana; Zielinska, Alexandra; Sanchez-Lopez, ElenaThe synthesis of silver nanoparticles using plant extracts is known as a green approach, as it does not require the use of high pressure, energy, high temperature, or toxic chemicals. The approach makes use of plant extracts in a process called bioreduction, which is mediated by enzymes, proteins, amino acids, and metabolites found in bark, seed, and leaf extracts, transforming silver ions into metallic silver....