2 documents found, page 1 of 1
Bone and Cytokine Markers Associated With Bone Disease in Systemic Mastocytosis
Rama, TA; Henriques, AF; Matito, A; Jara-Acevedo, M; Caldas, C; Mayado, A; Muñoz-González, JI; Moreira, A; Cavaleiro Rufo, J; García-Montero, ABackground Mastocytosis encompasses a heterogeneous group of diseases characterized by tissue accumulation of clonal mast cells, which frequently includes bone involvement. Several cytokines have been shown to play a role in the pathogenesis of bone mass loss in systemic mastocytosis (SM), but their role in SM-associated osteosclerosis remains unknown. Objective To investigate the potential association between ...
Mastocytosis presenting with mast cell-mediator release-associated symptoms eli...
Rama, TA; Morgado, JM; Henriques, A; Escribano, L; Alvarez-Twose, I; Sanchez-Muñoz, L; Moreira, A; Romão, J; Órfão, A; Matito, ABackground: Nonsteroidal anti-inflammatory drugs (NSAIDs) are frequently avoided in mastocytosis, because of a potential increased risk for drug hypersensitivity reactions (DHRs) due to inhibition of cyclo-oxygenase (COX), subsequent depletion of prostaglandin E2 and release of leukotrienes. Objectives: Here, we aimed at determining the prevalence of mast cell (MC) mediator release symptoms triggered by NSAIDs ...