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Ketamine combined with psychotherapy for treatment-resistant depression

Cohen, Rebeca; Bastos, João; Cunha, Catarina; Marguilho, Miriam; Sancho, Ana; Silva, Maria João Matos; King, Franklin; Castro-Rodrigues, Pedro

Ketamine, an N -methyl- d -aspartate antagonist, shows promise for treatment-resistant depression (TRD), with psychedelic doses potentially enhancing efficacy. However, its transient antidepressant effects and the need for repeated infusions raise concerns about optimal duration and long-term safety. Two clinical trials have tested the combination of ketamine with psychotherapy for depression, with mixed result...


Portuguese validation of the Functional Assessment of Communication Skills for ...

Leal, Gabriela; Sancho, Ana

The purpose of this study was to adapt and validate Functional Assessment of Communication Skills for Adults of American Speech-Language-Hearing Association (ASHA-FACS) (Fratalli et al., 1995) which evaluates the functional communication of adults who have speech, language, or cognitive impairments. This instrument consists in 43 items divided in four domains: social communication; communication of basic needs;...

Date: 2012   |   Origin: Cadernos de Saúde

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