11 documents found, page 1 of 2
Evidência para o efeito de um “gene principal” do hospedeiro na suscetibilidade...
David, Susana; Mateus, Ana R.A.; Duarte, Elsa L.; Albuquerque, José; Portugal, Clara; Sancho, Luísa; Lavinha, João; Gonçalves, GuilhermeA análise do genoma do patógeno e da genética do hospedeiro tem possibilitado o entendimento da coevolução do Mycobacterium tuberculosis com o seu hospedeiro humano, conduzindo a relações simpátricas mais estáveis entre o hospedeiro e o patógeno. A influência de fatores clínicos (coinfeção pelo VIH e tuberculose multirresistente (MDRTB]) e demográficos (sexo e idade) na relação hospedeiro-patógeno simpátrica fo...
Genetic Background and Expression of the New qepA4 Gene Variant Recovered in Cl...
Manageiro, Vera; Félix, David; Jones-Dias, Daniela; Sampaio, Daniel A; Vieira, Luís; Sancho, Luísa; Ferreira, Eugénia; Caniça, ManuelaA new QepA4 variant was detected in an O86:H28 ST156-fimH38 Escherichia coli, showing a multidrug-resistance phenotype. PAβN inhibition ofqepA4-harboring transconjugant resulted in increase of nalidixic acid accumulation. TheqepA4andcatA1genes were clustered in a 26.0-kp contig matching an IncF-type plasmid, and containing a Tn21-type transposon with multiple mobile genetic elements. This QepA variant is worris...
Determinants of the Sympatric Host-Pathogen Relationship in Tuberculosis
David, Susana; Mateus, A. R. A.; Duarte, Elsa L.; Albuquerque, José; Portugal, Clara; Sancho, Luísa; Lavinha, João; Gonçalves, GuilhermeMajor contributions from pathogen genome analysis and host genetics have equated the possibility of Mycobacterium tuberculosis co-evolution with its human host leading to more stable sympatric host–pathogen relationships. However, the attribution to either sympatric or allopatric categories depends on the resolution or grain of genotypic characterization. We explored the influence on the sympatric host-pathogen...
Resistência ao imipenemo em clone endémico de Clostridium difficile do ribotipo...
Isidro, Joana; Santos, Andrea; Nunes, Alexandra; Borges, Vítor; Silva, Catarina; Chaves, Catarina; Sancho, Luísa; Vieira, Luís; Gomes, João PauloObjetivos: Identificar estirpes clínicas resistentes aos carbapenemos; Caracterizar perfil de resistência; Identificar mecanismos de resistência; Avaliar a proximidade genética entre estirpes.
Extended-Spectrum Beta-Lactamase-Producing Enterobacteriaceae Susceptibility to...
Brito, Tiago; Portugal, Clara; Sancho, Luísa; Carvalho, Carina; Grima, Bruno; Delgado Alves, JoséIntroduction: The rising frequency of extended spectrum Beta-lactamase (ESBL) producing Enterobacteriaceae in recent years represents an important public health issue, with scarce effective alternatives for treatment. Several international studies have demonstrated very high in vitro susceptibility of these bacteria to fosfomycin. The clinical efficiency of this treatment was tested on acute uncomplicated cysti...
Determinants of the Sympatric Host-Pathogen Relationship in Tuberculosis
David, Susana; Mateus, A. R. A.; Duarte, Elsa L.; Albuquerque, José; Portugal, Clara; Sancho, Luísa; Lavinha, João; Gonçalves, GuilhermeMajor contributions from pathogen genome analysis and host genetics have equated the possibility of Mycobacterium tuberculosis co-evolution with its human host leading to more stable sympatric host-pathogen relationships. However, the attribution to either sympatric or allopatric categories depends on the resolution or grain of genotypic characterization. We explored the influence on the sympatric host-pathogen...
Determinants of the Sympatric Host-Pathogen Relationship in Tuberculosis
David, Susana; Mateus, A.R.A.; Duarte, Elsa; Albuquerque, José Maria; Portugal, Clara; Sancho, Luísa; Lavinha, João; Gonçalves, GuilhermeMajor contributions from pathogen genome analysis and host genetics have equated the possibility of Mycobacterium tuberculosis co-evolution with its human host leading to more stable sympatric host–pathogen relationships. However, the attribution to either sympatric or allopatric categories depends on the resolution or grain of genotypic haracterization. We explored the influence on the sympatric host-pathogen ...
Tuberculosis diagnosis after bleach processing for early stage tuberculosis lab...
David, Susana; Sutre, AF; Sanca, A; Mané, A; Henriques, V; Portugal, Clara; Sancho, Luísa; Cardoso, A; Paixão, Eleonora; Duarte, EL; Leite, CQFThe diagnosis of tuberculosis is seriously hampered in the absence of standard biosafety laboratory facilities for specimen concentration and Mycobacterium tuberculosis culture. Within a laboratory twinning arrangement,heat-fixed direct smear and sediment from 74 bleach-processed and 20 non-processed specimens from Cumura Hospital, Guinea-Bissau, were sent to Lisbon for molecular evaluation of rifampicin resist...
Implication of the RDRIO Mycobacterium tuberculosis sublineage in multidrug res...
David, Susana; Duarte, EL; Leite, CQF; Paixão, Eleonora; Ribeiro, João Nuno; Maio, José; Portugal, Clara; Sancho, Luísa; Germano de Sousa, JoséMultidrug and extensively drug resistant Mycobacterium tuberculosis are a threat to tuberculosis control programs. Genotyping methods, such as spoligotyping and MIRU–VNTR typing (Mycobacterial Interspersed Repetitive Units), are useful in monitoring potentially epidemic strains and estimating strain phylogenetic lineages and/or genotypic families. M. tuberculosis Latin American Mediterranean (LAM)family is a ma...
Tuberculosis diagnosis after bleach processing for early stage tuberculosis lab...
David, Susana; Sutre, Ana Filipa; Sanca, Armando; Mané, Alfredo; Henriques, Victor; Portugal, Clara; Sancho, Luísa; Cardoso, Ana; Paixão, EleonoraThe diagnosis of tuberculosis is seriously hampered in the absence of standard biosafety laboratory facilities for specimen concentration and Mycobacterium tuberculosis culture. Within a laboratory twinning arrangement, heat-fixed direct smear and sediment from 74 bleach-processed and 20 non-processed specimens from Cumura Hospital, Guinea-Bissau, were sent to Lisbon for molecular evaluation of rifampicin resis...