4 documents found, page 1 of 1
Preeclampsia and Gestational Hypertension: Biochemical and Antioxidant Features...
Galvão,Victoria Elizabeth; Cavalli,Ricardo Carvalho; Sandrim,Valeria CristinaAbstract Objective Gestational hypertension (GH) is characterized by increased blood pressure after the 20th gestational week; the presence of proteinuria and/or signs of end-organ damage indicate preeclampsia (PE). Heme oxygenase-1 (HO-1) is an antioxidant enzyme with an important role in maintaining endothelial function, and induction of HO-1 by certain molecules shows potential in attenuating the condition’s...
Interaction Between NOS3 and HMOX1 on Antihypertensive Drug Responsiveness in P...
Sandrim,Valeria Cristina; Luizon,Marcelo Rizzatti; Pilan,Eliane; Caldeira-Dias,Mayara; Coeli-Lacchini,Fernanda Borchers; Kors,Georgia; Berndt,IulyAbstract Objective We examined the interaction of polymorphisms in the genes heme oxygenase- 1 (HMOX1) and nitric oxide synthase (NOS3) in patients with preeclampsia (PE) as well as the responsiveness to methyldopa and to total antihypertensive therapy. Methods The genes HMOX1 (rs2071746, A/T) and NOS3 (rs1799983, G/T) were genotyped using TaqMan allele discrimination assays (Applied Biosystems, Foster City, CA...
Consumption of animal-based and processed food associated with cardiovascular r...
Acosta-Navarro,Júlio César; Oki,Adriana Midori; Antoniazzi,Luiza; Bonfim,Maria Aparecida Carlos; Hong,Valeria; Gaspar,Maria Cristina de AlmeidaSUMMARY OBJECTIVE To evaluate the frequency of food consumption in apparently healthy men and their association with cardiovascular risk factors and biomarkers of subclinical atherosclerosis. METHODS In this observational study, 88 men had their food standard obtained through the food frequency questionnaire (FFQ). Associations of dietary patterns with cardiovascular risk factors, such as anthropometric data, l...
Circulating Tissue Inhibitor of Metalloproteinase-4 levels are not a Predictor ...
Sandrim,Valeria Cristina; Machado,Jackeline; Bettiol,Heloisa; Barbieri,Marco Antonio; Cardoso,Viviane Cunha; Palei,Ana CarolinaAbstract Objective To evaluate whether the circulating level of tissue inhibitor of metalloproteinase- 4 (TIMP-4) in the period between 20 and 25 weeks of gestation is a predictor of preeclampsia. Methods We have performed a case-control study, nested in a prospective study cohort in Ribeirão Preto, in the state of São Paulo, Brazil. Of the 1,400 pregnant women evaluated between 20 and 25 weeks of gestation, 46...