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Increased Intake of Both Caffeine and Non-Caffeine Coffee Components Is Associa...
Coelho, Margarida; Patarrão, Rita S.; Sousa-Lima, Inês; Ribeiro, Rogério T.; Meneses, Maria João; Andrade, Rita; Mendes, Vera M.; Manadas, BrunoCoffee may protect against non-alcoholic fatty liver disease (NAFLD), but the roles of the caffeine and non-caffeine components are unclear. Coffee intake by 156 overweight subjects (87% with Type-2-Diabetes, T2D) was assessed via a questionnaire, with 98 subjects (all T2D) also providing a 24 h urine sample for quantification of coffee metabolites by LC-MS/MS. NAFLD was characterized by the fatty liver index (...
Interpersonal Relationships in Diabetes: Views and Experience of People with Di...
Nascimento do Ó, Dulce; Serrabulho, Lurdes; Ribeiro, Rogério T.; Silva, Sónia; Covinhas, Ana; Afonso, Maria João; Boavida, José ManuelIntroduction: The increasing burden of diabetes poses a great challenge to healthcare systems and economy worldwide. Although modern therapeutic strategies for diabetes are widely available, most patients still fail to achieve optimal clinical targets and well-being. The primary objective of this study was to assess and explore potential drivers and successful management of diabetes among people with diabetes, ...
Loss of postprandial insulin clearance control by Insulin-degrading enzyme driv...
Borges, Diego O; Patarrão, Rita S; Ribeiro, Rogério T.; de Oliveira, Rita Machado; Duarte, Nádia; Belew, Getachew Debas; Martins, MadalenaSystemic insulin availability is determined by a balance between beta-cell secretion capacity and insulin clearance (IC). Insulin-degrading enzyme (IDE) is involved in the intracellular mechanisms underlying IC. The liver is a major player in IC control yet the role of hepatic IDE in glucose and lipid homeostasis remains unexplored. We hypothesized that IDE governs postprandial IC and hepatic IDE dysfunction am...
Insights from qualitative research on NAFLD awareness with a cohort of T2DM pat...
Alemany-Pagès, Mireia; Moura-Ramos, Mariana; Araújo, Sara; Macedo, Maria Paula; Ribeiro, Rogério T.; do Ó, Dulce; Santos, João RamalhoIt is estimated that around 70% of Type 2 Diabetes Mellitus patients (T2DM) have Non-Alcoholic Fatty Liver Disease (NAFLD). Awareness and education are amongst the major shortcomings of the public health response to the increasing threat of NAFLD. Characterizing the specific NAFLD-related information needs of particular high-risk metabolic communities, for instance, T2DM patients, might aid in the development o...
Effects of combined training with different intensities on vascular health in p...
Magalhães, João P.; Melo, Xavier; Correia, Inês; Ribeiro, Rogério T.; Raposo, João; Dores, Hélder; Bicho, Manuel; Sardinha, Luís B.Background: Exercise, when performed on a regular basis, is a well-accepted strategy to improve vascular function in patients with type 2 diabetes. However, the exercise intensity that yields maximal adaptations on structural and functional indices in patients with type 2 diabetes remains uncertain. Our objective was to analyze the impact of a 1-year randomized controlled trial of combined high-intensity interv...
Dermic diffusion and stratum corneum: a state of the art review of mathematical...
Couto, Ana; Fernandes, Ruben; Cordeiro, M. Natália D. S.; Reis, Sara S.; Ribeiro, Rogério T.; Pessoa, Ana S. MouraTransdermal biotechnologies are an ever increasing field of interest, due to the medical and pharmaceutical applications that they underlie. There are several mathematical models at use that permit a more inclusive vision of pure experimental data and even allow practical extrapolation for new dermal diffusion methodologies. However, they grasp a complex variety of theories and assumptions that allocate their us...