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Mesenteric hypoperfusion and inflammation induced by brain death are not affect...

Simas, Rafael; Ferreira, Sueli G.; Menegat, Laura; Zanoni, Fernando L.; Correia, Cristiano J.; Silva, Isaac A.; Sannomiya, Paulina; Moreira, Luiz F.P.

OBJECTIVES: Brain death is typically followed by autonomic changes that lead to hemodynamic instability, which is likely associated with microcirculatory dysfunction and inflammation. We evaluated the role of the microcirculation in the hemodynamic and inflammatory events that occur after brain death and the effects of autonomic storm inhibition via thoracic epidural blockade on mesenteric microcirculatory chan...

Date: 2015   |   Origin: Oasisbr

Effects of ethyl pyruvate on leukocyte-endothelial interactions in the mesenter...

Guarda, Ismael Francisco Mota Siqueira; Correia, Cristiano Jesus; Breithaupt-Faloppa, Ana Cristina; Ferreira, Sueli Gomes; Moreno, Ana Carolina Ramos

OBJECTIVES: Experimental studies on sepsis have demonstrated that ethyl pyruvate is endowed with antioxidant and anti-inflammatory properties. This study aimed to investigate the effects of ethyl pyruvate on leukocyte-endothelial interactions in the mesenteric microcirculation in a live Escherichia coli-induced sepsis model in rats. METHODS: Male Wistar rats were administered an intravenous suspension of E. col...

Date: 2015   |   Origin: Oasisbr

Local and remote ischemic preconditioning protect against intestinal ischemic/r...

Erling Junior, Nilon; Montero, Edna Frasson de Souza; Sannomiya, Paulina; Poli-de-Figueiredo, Luiz Francisco

OBJECTIVES: This study tests the hypothesis that local or remote ischemic preconditioning may protect the intestinal mucosa against ischemia and reperfusion injuries resulting from temporary supraceliac aortic clamping. METHODS: Twenty-eight Wistar rats were divided into four groups: the sham surgery group, the supraceliac aortic occlusion group, the local ischemic preconditioning prior to supraceliac aortic oc...

Date: 2013   |   Origin: Oasisbr

Paradoxical effects of brain death and associated trauma on rat mesenteric micr...

Simas, Rafael; Sannomiya, Paulina; Cruz, José Walber M. C; Correia, Cristiano de Jesus; Zanoni, Fernando Luiz; Kase, Maurício; Menegat, Laura

OBJECTIVE: Experimental findings support clinical evidence that brain death impairs the viability of organs for transplantation, triggering hemodynamic, hormonal, and inflammatory responses. However, several of these events could be consequences of brain death-associated trauma. This study investigated microcirculatory alterations and systemic inflammatory markers in brain-dead rats and the influence of the ass...

Date: 2012   |   Origin: Oasisbr

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