18 documents found, page 1 of 2
Anaphylaxis in the Pediatric Emergency Department of a central hospital
Coelho, Cristina; Pereira, Liliana Patrícia; Santa, Cátia; Pedrosa, CláudiaAnaphylaxis is a potentially life-threatening medical emergency. Early diagnosis and treatment are crucial. In children, the diagnosis is complicated by some unique features of the pediatric population. Food is the most common etiology in pediatric patients. The aim of this study was to characterize the episodes of anaphylaxis identified in the Pediatric Emergency Department (ED) of a central hospital between 2...
Chronic treatment with D2-antagonist haloperidol leads to inhibitory/excitatory...
Santa, Cátia; Rodrigues, Diana; Coelho, Joana F.; Anjo, Sandra I.; Mendes, Vera M.; Bessa-Neto, Diogo; Dunn, Michael J.; Cotter, David; Baltazar, GraçaStriatal dysfunction has been implicated in the pathophysiology of schizophrenia, a disorder characterized by positive symptoms such as hallucinations and delusions. Haloperidol is a typical antipsychotic medication used in the treatment of schizophrenia that is known to antagonize dopamine D2 receptors, which are abundantly expressed in the striatum. However, haloperidol's delayed therapeutic effect also sugge...
Proteome dataset of sea bass (Dicentrarchus labrax) skin-scales exposed to fluo...
Anjos, Liliana; Pinto, Patrícia I. S.; Santos, Soraia; Estêvão, M. Dulce; Santa, Cátia; Manadas, Bruno; Canário, Adelino V. M.; Power, Deborah M.Contamination of aquatic ecosystems with anthropogenic pollutants, including pharmaceutical drugs, is a major concern worldwide. Aquatic organisms such as fish are particularly at risk of exposure to pollutants. The surface of fish is the first point of contact with pollutants, but few studies have considered the impact of pollutants on the skin-scale barrier. The present proteome data are the basis of the find...
Systematic Review and Meta-Analysis of Mass Spectrometry Proteomics Applied to ...
Rodrigues, João E.; Martinho, Ana; Santa, Cátia; Madeira, Nuno; Coroa, Manuel; Santos, Vítor; Martins, Maria J.; Pato, Carlos N.; Macedo, AntónioMass spectrometry (MS)-based techniques can be a powerful tool to identify neuropsychiatric disorder biomarkers, improving prediction and diagnosis ability. Here, we evaluate the efficacy of MS proteomics applied to human peripheral fluids of schizophrenia (SCZ) patients to identify disease biomarkers and relevant networks of biological pathways. Following PRISMA guidelines, a search was performed for studies t...
Systematic Review and Meta-Analysis on MS-Based Proteomics Applied to Human Per...
Rodrigues, Joao E.; Martinho, Ana; Santos, Vítor; Santa, Cátia; Madeira, Nuno; Martins, Maria J.; Pato, Carlos N.; Macedo, António; Manadas, BrunoBipolar disorder (BD) is a clinically heterogeneous condition, presenting a complex underlying etiopathogenesis that is not sufficiently characterized. Without molecular biomarkers being used in the clinical environment, several large screen proteomics studies have been conducted to provide valuable molecular information. Mass spectrometry (MS)-based techniques can be a powerful tool for the identification of d...
Proteome dataset of sea bass (Dicentrarchus labrax) skin-scales exposed to fluo...
L, Anjos; PI Pinto, PPinto; Santos, Soraia; Estêvão, M. Dulce; Santa, Cátia; Manadas, Bruno; Canario, A.V.M.; Power, DeborahContamination of aquatic ecosystems with anthropogenic pollutants, including pharmaceutical drugs, is a major concern worldwide. Aquatic organisms such as fish are particularly at risk of exposure to pollutants. The surface of fish is the first point of contact with pollutants, but few studies have considered the impact of pollutants on the skin-scale barrier. The present proteome data are the basis of the find...
Disclosing proteins in the leaves of cork oak plants associated with the immune...
Coelho, Ana Cristina; Pires, Rosa; Schütz, Gabriela; Santa, Cátia; Manadas, Bruno; Pinto, PatríciaThe pathological interaction between oak trees and Phytophthora cinnamomi has implications in the cork oak decline observed over the last decades in the Iberian Peninsula. During host colonization, the phytopathogen secretes effector molecules like elicitins to increase disease effectiveness. The objective of this study was to unravel the proteome changes associated with the cork oak immune response triggered b...
Disclosing proteins in the leaves of cork oak plants associated with the immune...
Coelho, Ana Cristina; Pires, Rosa; Schütz, Gabriela; Santa, Cátia; Manadas, Bruno; Pinto, Patricia ISThe pathological interaction between oak trees and Phytophthora cinnamomi has implications in the cork oak decline observed over the last decades in the Iberian Peninsula. During host colonization, the phytopathogen secretes effector molecules like elicitins to increase disease effectiveness. The objective of this study was to unravel the proteome changes associated with the cork oak immune response triggered b...
Influence of EPICardial adipose tissue in HEART diseases (EPICHEART) study: Pro...
Mancio, Jennifer; Barros, António S.; Conceicão, Glória; Santa, Cátia; Pessoa-Amorim, Guilherme; Bartosch, Carla; Fragao-Marques, MarianaAccumulation of epicardial adipose tissue (EAT) is associated with coronary artery disease (CAD) and increased risk of coronary events in asymptomatic subjects and low-risk patients, suggesting that EAT promotes atherosclerosis in its early stage. Recent studies have shown that the presence of CAD affects the properties of adjacent EAT, leading to dynamic changes in the molecular players involved in the interpl...
Proteomic analysis of tissue-specific protein aggregation signatures throughout...
Francisco, Stephany; Nobre, Ana; Ferreira, Margarida; Santa, Cátia; Anjo, Sandra; Manadas, Bruno; Santos, Manuel; Soares, AnaProteome and proteostasis network ( disruptions lead to proteostasis imbalances and accumulation of protein aggregates, characteristic of several age related diseases 1 3 The consequences of PN disturbances in the context of healthy aging remains to be thoroughly studied in mammals To determine whether accumulation of insoluble proteins occurs during mammalian aging, young adult 6 month old), middle aged 13 mon...