6 documents found, page 1 of 1
Functional analysis of vif protein shows less restriction of human immunodefici...
Ribeiro, AC; Silva, AME; Silva, AME; Santa-Marta, M; Pombo, A; Moniz-Pereira, J; Goncalves, J; Barahona, IViral infectivity factor (Vif) is one of the human immunodeficiency virus (HIV) accessory proteins and is conserved in the primate lentivirus group. This protein is essential for viral replication in vivo and for productive infection of nonpermissive cell
HIV-1 Vif can directly inhibit apolipoprotein B mRNA-editing enzyme catalytic p...
Santa-Marta, M; da Silva, FA; Fonseca, AM; Goncalves, JThe human apolipoprotein B mRNA-editing enzyme catalytic polypeptide-like 3G (APOBEC3G), also known as CEM-15, is a host-cell factor involved in innate resistance to retroviral infection. HIV-1 viral infectivity factor (Vif) protein was shown to protect t
Phosphorylation of a novel SOCS-box regulates assembly of the HIV-1 Vif-Cul5 co...
Mehle, A; Goncalves, J; Santa-Marta, M; McPike, M; Gabuzda, DHIV-1 Vif (viral infectivity factor) protein overcomes the antiviral activity of the DNA deaminase APOBEC3G by targeting it for proteasomal degradation. We report here that Vif targets APOBEC3G for degradation by forming an SCF-like E3 ubiquitin ligase co
Camelized rabbit-derived VH single-domain Intrabodies Against vif strongly neut...
da Silva, FA; Santa-Marta, M; Freitas-Vieira, A; Mascarenhas, P; Barahona, I; Moniz-Pereira, J; Gabuzda, D; Goncalves, JWe recently developed a specific single-chain antibody from immunized rabbits to HIV-1 Vif protein that was expressed intracellularly and inhibited reverse transcription and viral replication. The Vif of HIV-1 overcomes the innate antiviral activity of a
Functional neutralization of HIV-1 Vif protein by intracellular immunization in...
Goncalves, J; Silva, F; Freitas-Vieira, A; Santa-Marta, M; Malho, R; Yang, X; Gabuzda, D; Barbas, CHuman immunodeficiency virus type 1 (HIV-1) encoded Vif protein is important for viral replication and infectivity. Therefore, Vif is considered to be an important alternative therapeutic target for inhibition of viral infectivity at the level of viral as
Functional neutralization of HIV-1 Vif protein by intracellular immunization in...
Goncalves, J; Silva, F; Freitas-Vieira, A; Santa-Marta, M; Malho, R; Yang, XY; Gabuzda, D; Barbas, CHuman immunodeficiency virus type 1 (HIV-1)-encoded Vif protein is important for viral replication and infectivity. Vif is a cytoplasmic protein that acts during virus assembly by an unknown mechanism, enhancing viral infectivity. The action of Vif in producer cells is essential for the completion of proviral DNA synthesis following virus entry. Therefore, Vif is considered to be an important alternative therap...