2 documents found, page 1 of 1
Determination of nimodipine in plasma by HPLC-MS/MS and pharmacokinetic applica...
Nascimento, Demétrius Fernandes do; Moraes Filho, Manoel Odorico de; Bezerra, Fernando Antônio Frota; Pontes, Andréa Vieira; Uchoa, Célia Regina AmaralTo develop and validate a rapid, specific and highly sensitive method to quantify nimodipine in human plasma using dibucaine as the internal standard (IS). The analyte and IS were extracted from plasma samples by liquid-liquid extraction using hexane-ethyl acetate (1:1 v/v). The chromatographic separation was performed on a Varian ® Polaris C18 analytical column (3 m m, 50 x 2.0 mm) and pre-column Securityguard...
Determination of nimodipine in plasma by HPLC-MS/MS and pharmacokinetic applica...
Nascimento, Demétrius Fernandes do; Moraes, Manoel Odorico de; Bezerra, Fernando Antônio Frota; Pontes, Andréa Vieira; Uchoa, Célia Regina AmaralTo develop and validate a rapid, specific and highly sensitive method to quantify nimodipine in human plasma using dibucaine as the internal standard (IS). The analyte and IS were extracted from plasma samples by liquid-liquid extraction using hexane-ethyl acetate (1:1 v/v). The chromatographic separation was performed on a Varian® Polaris C18 analytical column (3 μm, 50 x 2.0 mm) and pre-column Securitygu...