20 documents found, page 1 of 2
Enhanced il-6 and il-12b gene expression after SARS-CoV-2 infection in leprosy ...
Morais Júnior, Gilberto Santos; Kurizky, Patricia Shu; Cerqueira, Selma Regina Penha Silva; Barroso, Daniel Holanda; Schulte, Heidi LuiseExperts have called attention to the possible negative impact of the coronavirus disease 2019 (COVID19)–related cytokine storm syndrome on the progression of leprosy-related disabilities. We assessed the frequency of reactional states in patients co-infected with Mycobacterium leprae and severe acute respiratory syndrome (SARS) coronavirus (CoV) 2 (SARS-CoV-2). We consecutively included patients during the firs...
Enhanced il-6 and il-12b gene expression after SARS-CoV-2 infection in leprosy ...
Morais Júnior, Gilberto Santos; Kurizky, Patricia Shu; Cerqueira, Selma Regina Penha Silva; Barroso, Daniel Holanda; Schulte, Heidi LuiseExperts have called attention to the possible negative impact of the coronavirus disease 2019 (COVID-19)–related cytokine storm syndrome on the progression of leprosy-related disabilities. We assessed the frequency of reactional states in patients co-infected with Mycobacterium leprae and severe acute respiratory syndrome (SARS) coronavirus (CoV) 2 (SARS-CoV-2). We consecutively included patients during the fir...
Triatomines : trypanosomatids, bacteria, and viruses potential vectors?
Vieira, Caroline Barreto; Praça, Yanna Reis; Bentes, Kaio Luís da Silva; Santiago, Paula Beatriz; Silva, Sofia Marcelino MartinsTriatominae bugs are the vectors of Chagas disease, a major concern to public health especially in Latin America, where vector-borne Chagas disease has undergone resurgence due mainly to diminished triatomine control in many endemic municipalities. Although the majority of Triatominae species occurs in the Americas, species belonging to the genus Linshcosteus occur in India, and species belonging to the Triatom...
Revealing a novel Otubain-Like Enzyme from Leishmania infantum with deubiquitin...
Azevedo, Clênia dos Santos; Guido, Bruna Cândido; Pereira, Jhonata L.; Nolasco, Diego O.; Corrêa, Rafael; Magalhães, Kelly Grace; Motta, Flávia NaderDeubiquitinating enzymes (DUBs) play an important role in regulating a variety of eukaryotic processes. In this context, exploring the role of deubiquitination in Leishmania infantum could be a promising alternative to search new therapeutic targets for leishmaniasis. Here we present the first characterization of a DUB from L. infantum, otubain (OtuLi), and its localization within parasite. The recombinant OtuL...
Insight into the Exoproteome of the tissue derived trypomastigote form of Trypa...
Queiroz, Rayner Myr Lauterjung; Ricart, Carlos André Ornelas; Machado, Mara Olimpia; Bastos, Izabela Marques Dourado; Santana, Jaime Martins deThe protozoan parasite Trypanosoma cruzi causes Chagas disease, one of the major neglected infectious diseases. It has the potential to infect any nucleated mammalian cel . The secreted/excreted protein repertoire released by T. cruzi try pomastigotes is crucial in host-pathogen interactions. In this study, mammalian tissue culture derived trypomastigotes (Ystrain) were used to characterize ethe exoproteome of ...
The activity of a Hexameric M17 Metallo-Aminopeptidase is associated with survi...
Corrêa, André França; Bastos, Izabela Marques Dourado; Neves, David; Kipnis, André; Kipnis, Ana Paula Junqueira; Santana, Jaime Martins deMycobacterium tuberculosis is one of the most prevalent human pathogens causing millions of deaths in the last years. Moreover, tuberculosis (TB) treatment has become increasingly challenging owing to the emergence of multidrug resistant M. tuberculosis strains. Thus, there is an immediate need for the development of new anti-TB drugs. Proteases appear to be a promising approach and may lead to shortened and ef...
Proteases of haematophagous arthropod vectors are involved in blood-feeding, yo...
Santiago, Paula Beatriz; Araújo, Carla Nunes de; Motta, Flávia Nader; Praça, Yanna Reis; Charneau, Sébastien; Bastos, Izabela Marques DouradoTicks, triatomines, mosquitoes and sand flies comprise a large number of haematophagous arthropods considered vectors of human infectious diseases. While consuming blood to obtain the nutrients necessary to carry on life functions, these insects can transmit pathogenic microorganisms to the vertebrate host. Among the molecules related to the blood-feeding habit, proteases play an essential role. In this review,...
Leishmania infantum and Leishmania braziliensis : differences and similarities ...
Falcão, Sarah de Athayde Couto; Jaramillo, Tatiana María Giraldo; Ferreira, Luciana G.; Bernardes, Daniela M.; Santana, Jaime Martins deVisceral leishmaniasis is a severe form of the disease, caused by Leishmania infantum in the New World. Patients present an anergic immune response that favors parasite establishment and spreading through tissues like bone marrow and liver. On the other hand, Leishmania braziliensis causes localized cutaneous lesions, which can be self-healing in some individuals. Interactions between host and parasite are esse...
New binding site conformations of the dengue virus NS3 Protease accessed by mol...
Almeida, Hugo de; Bastos, Izabela Marques Dourado; Ribeiro, Bergmann Morais; Maigret, Bernard; Santana, Jaime Martins deDengue fever is caused by four distinct serotypes of the dengue virus (DENV1-4), and is estimated to affect over 500 million people every year. Presently, there are no vaccines or antiviral treatments for this disease. Among the possible targets to fight dengue fever is the viral NS3 protease (NS3PRO), which is in part responsible for viral processing and replication. It is now widely recognized that virtual sc...
Dendritic cells : a double-edged sword in immune responses during chagas disease
Jaramillo, Natalia Gil; Motta, Flávia Nader; Favali, Cecilia Beatriz Fiuza; Bastos, Izabela Marques Dourado; Santana, Jaime Martins deDendritic cells (DCs) are the most important member of the antigen presenting cells group due to their ability to recognize antigen at the infection site and their high specialized antigen internalization capacity. These cells have central role in connecting the innate and adaptive immune responses against Trypanosoma cruzi, the causative agent of Chagas disease. These first line defense cells modulate host imm...