3 documents found, page 1 of 1
Cyclodextrin-complexed Ocimum basilicum leaves essential oil increases fos prot...
Nascimento, Simone de Souza; Araujo, Adriano Antunes de Souza; Brito, Renan Guedes de; Serafini, Mairim Russo; Menezes, Paula dos PassosO. basilicum leaves produce essential oils (LEO) rich in monoterpenes. The short half-life and water insolubility are limitations for LEO medical uses. β-Cyclodextrin (β-CD) has been employed to improve the pharmacological properties of LEO. We assessed the antihyperalgesic profile of LEO, isolated or complexed in β-CD (LEO/β-CD), on an animal model for fibromyalgia. Behavioral tests: mice were treated every da...
Cyclodextrin-complexed Ocimum basilicum leaves essential oil increases Fos prot...
Nascimento, Simone de Souza; Araujo, Adriano Antunes de Souza; Brito, Renan Guedes de; Serafini, Mairim Russo; Menezes, Paula dos PassosO. basilicum leaves produce essential oils (LEO) rich in monoterpenes. The short half-life and water insolubility are limitations for LEO medical uses. β-Cyclodextrin (β-CD) has been employed to improve the pharmacological properties of LEO. We assessed the antihyperalgesic profile of LEO, isolated or complexed in β-CD (LEO/β-CD), on an animal model for fibromyalgia. Behavioral tests: mice were treated every da...
Bioassay-guided evaluation of antinociceptive effect of N-salicyloyltryptamine:...
Quintans-Júnior, Lucindo José; Silva, Davi Antas; Quintans, Jullyana de Souza Siqueira; Araújo, Adriano Antunes de Souza; Siqueira, Rosana de SouzaWe investigated the antinociceptive and nerve excitability effects of the N-salicyloyltryptamine (NST) NST-treated mice exhibited a significant decrease in the number of writhes when 100 and 200 mg/kg (i.p.) were administered (i.p.). This effect was not antagonized by naloxone (1.5 mg/kg, i.p.). NST inhibited the licking response of the injected paw when 100 and 200 mg/kg were administered (i.p.) to mice in the...