3 documents found, page 1 of 1
Citral reduces nociceptive and inflammatory response in rodents
Quintans-Júnior, Lucindo José; Guimarães, Adriana Gibara; Santana, Marília Trindade de; Araújo, Bruno Eduardo Silva de; Moreira, Flávia VianaCitral (CIT), which contains the chiral enantiomers, neral (cis) and geranial (trans), is the majority monoterpene from Lippia alba and Cymbopogon citratus. The present study aimed to evaluate CIT for antinociceptive and anti-inflammatory activities in rodents. Antinociceptive and anti-inflammatory effects were studied by measuring nociception through acetic acid and formalin tests, while inflammation was verif...
Phytochemical screening, antinociceptive and anti-inflammatory effects of the e...
Andrade, Gilmara S.; Guimarães, Adriana Gibara; Santana, Marília Trindade de; Siqueira, Rosana de Souza; Passos, Luiz OliveiraThis report aimed to investigate the chemical composition and possible antinociceptive and anti-inflammatory effects of the essential oil from fresh leaves of Myrcia pubiflora DC., Myrtaceae (EOMP), through different experimental tests. The essential oil of M. pubiflora (EOMP) was obtained by hydrodistillation, analyzed by GC-MS, and tested at doses of 25, 50, and 100 mg/kg (i.p.) in three different tests of no...
Ocimum basilicum leaf essential oil and (-)-linalool reduce orofacial nocicepti...
Venâncio, Antônio Medeiros; Marchioro, Murilo; Estevam, Charles dos Santos; Melo, Mônica Santos de; Santana, Marília Trindade deThe present study investigated the antinociceptive effects of Ocimum basilicum L. (Lamiaceae) leaf essential oil (LEO) and (-)-linalool (LIN) in formalin (2%)-, glutamate (25 µM)- and capsaicin (2.5 µg)- induced orofacial nociception models in mice. The involvement of these substances was further evaluated on the neuronal excitability of the hippocampal dentate gyrus. Male mice (n=8/group) were pretreated separ...