4 documents found, page 1 of 1
High efficacy of chloroquine-derived bile salts in Pluronic F127 micelles again...
Silva, Ana Teresa; Prudêncio, Miguel; Oliveira, Isabel S.; Nogueira, Fátima; Morais, Inês; Santana, Sofia; Ferraz, Ricardo; Workneh, Eyob A.Colloidal nanocarriers can play a key role in the efficacious delivery of drugs, including antimalarials. Here, we investigated the ability of polymeric micelles of the block copolymer F127 to act as nanovehicles for two organic salts derived from chloroquine and human bile acids, namely, chloroquinium cholate (iCQP1) and chloroquinium glycocholate (iCQP1g). We have previously reported the strong in vitro antip...
Repurposing antiplasmodial leads for cancer: Exploring the antiproliferative ef...
Fonte, Mélanie; Rôla, Catarina; Santana, Sofia; Ferraz, Ricardo; Prudêncio, Miguel; Almeida, Joana; Ferraz, Ricardo; Prudêncio, CristinaDrug repurposing and rescuing have been widely explored as cost-effective approaches to expand the portfolio of chemotherapeutic agents. Based on the reported antitumor properties of both trans-cinnamic acids and quinacrine, an antimalarial aminoacridine, we explored the antiproliferative properties of two series of N-cinnamoyl-aminoacridines recently identified as multi-stage antiplasmodial leads. The compound...
Design, synthesis and antiplasmodial evaluation of new amide-, carbamate-, and ...
Marinović, Marina; Rimac, Hrvoje; de Carvalho, Lais Pessanha; Rôla, Catarina; Santana, Sofia; Pavić, Kristina; Held, Jana; Prudêncio, MiguelMalaria, one of the oldest parasitic diseases, remains a global health threat, and the increasing resistance of the malaria parasite to current antimalarials is forcing the discovery of new, effective drugs. Harmicines, hybrid compounds in which harmine/β-carboline alkaloids and cinnamic acid derivatives are linked via an amide bond or a triazole ring, represent new antiplasmodial agents. In this work, we used ...
Eco: uma experiência à luz do ecoteatro
Santana, SofiaO presente projecto explora uma experiência à luz do ecoteatro. Pretende-se assim não só produzir uma performance teatral assente em preocupações de carácter ecológico, como também investigar como pode a ecologia ser mais do que uma temática da produção teatral. Através de uma breve historiografia da ecocrítica, da ecopolítica e do ecoteatro, são reunidas as diferentes perspectivas que norteiam uma possível car...