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Bioassay-guided evaluation of antinociceptive effect of N-salicyloyltryptamine:...

Quintans-Júnior, Lucindo José; Silva, Davi Antas; Quintans, Jullyana de Souza Siqueira; Araújo, Adriano Antunes de Souza; Siqueira, Rosana de Souza

We investigated the antinociceptive and nerve excitability effects of the N-salicyloyltryptamine (NST) NST-treated mice exhibited a significant decrease in the number of writhes when 100 and 200 mg/kg (i.p.) were administered (i.p.). This effect was not antagonized by naloxone (1.5 mg/kg, i.p.). NST inhibited the licking response of the injected paw when 100 and 200 mg/kg were administered (i.p.) to mice in the...

Date: 2013   |   Origin: Oasisbr
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