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Pyrimido[5,4-d]pyrimidine-based compounds as a novel class of antitrypanosomal ...
Lopes, Andre; Santarem, Nuno; Cordeiro-da-Silva, Anabela; Carvalho, M. AliceSleeping sickness and leishmaniasis are neglected tropical diseases that threaten millions of people. The currently available therapies present several limitations, including high toxicity, lack of efficacy, and emerging drug resistance, prompting a search for novel therapeutic agents. In this work, we designed, synthesized, and in vitro evaluated the activity of new pyrimido[5,4-d]pyrimidines against Trypanoso...
Date: 2022
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Origin: RepositóriUM - Universidade do Minho