18 documents found, page 1 of 2
Guidelines for the Diagnosis and Treatment of Uncomplicated (Non-Lymphogranulom...
Andrade, Pedro; Azevedo, Jacinta; Lisboa, Carmen; Fernandes, Cândida; Borrego, Maria José; Borges-Costa, João; Reis, Joel; Santiago, FelicidadeChlamydia trachomatis infection is the most prevalent sexually transmitted bacterial infection in the world. Being associated with a large number of asymptomatic carriers, the diagnosis is frequently challenging and requires appropriate laboratory testing. In Portugal, the incidence of the disease has been consistently increasing in recent years, meaning that special awareness is required for case identificatio...
Invasive and Subcutaneous Infections Caused by Filamentous Fungi: Report from a...
Veríssimo, Cristina; Toscano, Cristina; Ferreira, Teresa; Abreu, Gabriela; Simões, Helena; Diogo, José; Carvalho, Dinah; Santiago, Felicidade; Lima, AnaInvasive fungal infections (IFI) have significantly increased over the past years due to advances in medical care for the at-risk immunocompromised population. IFI are often difficult to diagnose and manage, and can be associated with substantial morbidity and mortality. This study aims to contribute to understanding the etiology of invasive and subcutaneous fungal infections, their associated risk factors, and...
Vesicle and bullae eruption
Lopes Costa, Mariana; Zarcos, Maria Manuel; Santiago, FelicidadeVaricella-zoster virus primoinfection, known as varicella or chickenpox, is very common in children. However, zoster reinfection is uncommon at this age, being sometimes associated with a history of varicella in the mother during pregnancy, child immunosuppression, or local trauma. In this case report, the authors present an exuberant form of zoster infection in a three-year-old boy with no prior history of var...
Emerging Cutaneous Phaeohyphomycosis Caused by Alternaria infectoria
Kieselová, Katarína; Gomes, Tiago; Santiago, Felicidade; Martinha, HenriqueAlternaria species belong to a group of opportunistic fungi that causes skin infection mainly in immunosuppressed patients. The authors describe two clinically distinct cases of cutaneous alternariosis caused by Alternaria infectoria in patients under prolonged corticosteroid treatment. Additionally, a brief review of published cases in portuguese patients is conducted.; As espécies Alternaria pertencem a um gr...
Insights into CANDLE Syndrome
Kieselová, Katarina; Santiago, Felicidade; Henrique, MartinhaChronic atypical neutrophilic dermatosis with lipodystrophy and elevated temperature (CANDLE) syndrome is a recently described chronic autoinflammatory disease, pathophysiologically related to intracellular proteasome/immunoproteasome dysfunction. This review chronicles the recognition of CANDLE syndrome, the developments in the understanding of the pathomechanism, genetic background, and the emerging therapeut...
Infantile Hemangiomas and Beta-Blockers: 10 Years After Therapeutic Revolution
Kieselová, Katarína; Santiago, FelicidadeInfantile hemangioma is the most common vascular tumor of childhood, characterized by an initial rapid growth in the first months of life and with gradual spontaneous involution in the first years. Despite its benign behavior and spontaneous regression, about 10% of infantile hemangiomas have a negative functional or cosmetic impact, thus requiring an effective treatment. In 2008, an accidental discovery of a f...
Pustular Eruptions in Children as Manifestations of Autoinflammatory Diseases
Santiago, Felicidade; Torrelo, AntonioNowadays, in clinical practice, when attending a child with a pustular eruption and systemic inflammation, it is mandatory to think of an autoinflammatory disease, once infectious causes have been ruled out. Although rare, autoinflammatory disease must be recognized as early as possible, accurately diagnosed (including gene testing), and treated with targeted therapy if available.; Atualmente, na prática clínic...
Etiologia das infeções fúngicas invasivas e subcutâneas: análise dos dados da R...
Veríssimo, Cristina; Toscano, Cristina; Ferreira, Teresa; Abreu, Gabriela; Simões, Helena; Diogo, José; Queirós, Ana Maria; Santiago, FelicidadeA epidemiologia das infeções fúngicas invasivas tem vindo a alterar-se com o surgimento de novos agentes etiológicos. A Rede Nacional de Vigilância Laboratorial de Infeções Fúngicas Invasivas e Subcutâneas (IFI) teve início em 2013 com o objetivo de melhor compreender a epidemiologia destas infeções em Portugal. O objetivo deste estudo é analisar os dados obtidos através da Rede entre junho de 2013 e setembro d...
Cutaneous Lesions as the First Manifestation of Multiple Myeloma: Two Case Reports
Kieselová, Katarína; Santiago, Felicidade; Ramos, Sofia; Cunha, Maria Fernanda; Henrique, MartinhaMultiple myeloma is a proliferative clonal disorder of plasma cells. The clinical presentation is highly variable, with recurrent infections, anemia, renal insufficiency or bone pain from osteolytic lesions as the main initial manifestations. Skin manifestations are unusual and mostly unspecific. We describe two patients with cutaneous lesions as the first sign of this hematologic malignancy: nodular deposits o...
Trichoscopy as a Clue to the Diagnosis
Kieselová, Katarína; Santiago, Felicidade; Guiote, Victória; Henrique, MartinhaA 43-year-old man presented to our department with generalized erythroderma since early childhood, previously treated with topical and systemic corticosteroids with only partial improvement. The physical examination revealed polycyclic erythematous scaly plaques on the trunk and extremities and lichenification of the body folds (Fig. 1). In addition to skin lesions, we observed sparse hair of both eyebrows and ...