4 documents found, page 1 of 1
Mono- and Dicationic DABCO/Quinuclidine Composed Nanomaterials for the Loading ...
Fernandes, AR; Sanchez-Lopez, E; Santini, A; Santos, T; Garcia, ML; Silva, AM; Souto, EBOil-in-water nanoemulsions (NEs) are considered a suitable nanotechnological approach to improve the eye-related bioavailability of lipophilic drugs. The potential of cationic NEs is prominent due to the electrostatic interaction that occurs between the positively charged droplets with the negatively charged mucins present in the tear film. This interaction offers prolonged NEs residence at the ocular surface, ...
Dabco-customized nanoemulsions: Characterization, cell viability and genotoxici...
Fernandes, AR; Santos, T; Granja, PL; Sanchez-Lopez, E; Santini, A; Garcia, ML; Silva, AM; Souto, EBQuaternary derivatives of 1,4-diazabicyclo[2.2.2]octane (DABCO) and of quinuclidine surfactants were used to develop oil-in-water nanoemulsions with the purpose of selecting the best long-term stable nanoemulsion for the ocular administration of triamcinolone acetonide (TA). The combination of the best physicochemical properties (i.e., mean droplet size, polydispersity index, zeta potential, osmolality, viscoel...
The therapeutic potential of Apigenin
Salehi, B; Venditti, A; Sharifi-Rad, M; Kregiel, D; Sharifi-Rad, J; Durazzo, A; Lucarini, M; Santini, A; Souto, EB; Novellino, E; Antolak, H; Azzini, ESeveral plant bioactive compounds have exhibited functional activities that suggest they could play a remarkable role in preventing a wide range of chronic diseases. The largest group of naturally-occurring polyphenols are the flavonoids, including apigenin. The present work is an updated overview of apigenin, focusing on its health-promoting effects/therapeutic functions and, in particular, results of in vivo ...
Linseed essential oil - Source of Lipids as Active Ingredients for Pharmaceutic...
Campos, J; Severino, P; Ferreira, C; Zielinska, A; Santini, A; Souto, S; Souto, EBLinseed - also known as flaxseed -, is known for its beneficial effects on animal health attributed to its composition, comprising omega-6 (linoleic) and omega-3 (α-linolenic) fatty acids, various dietary fibers and lignans, which have health benefits in reducing the risk of cancer and cardiovascular diseases, lowering the levels of LDL-cholesterol and relaxing the smooth muscle cells in arteries increasing the...