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Modified drug delivery systems for veterinary use: pharmaceutical development a...

Souto, Eliana B.; Barbosa, Catarina I.; Baldim, Iara; Campos, Joana R.; Fernandes, Ana R.; Mazzola, Priscila G.; Andreani, Tatiana; Dias, Isabel R.

Scientific research in the field of veterinary pharmacology has provided new opportunities for the development of modified release dosage forms, with the aim to improve therapeutic efficacy and reduce animal stress. The formulation of classical drug molecules with advanced biomaterials has become a new approach to increasing drug bioavailability and improving the therapeutic outcome. The main reasons for the de...


Multifunctional nutraceutical composition based on fermented spirulina, apple c...

Bartkiene, Elena; Starkute, Vytaute; Jomantaite, Ieva; Zokaityte, Egle; Mockus, Ernestas; Tolpeznikaite, Ernesta; Zokaityte, Gintare; Petrova, Penka

The main purpose of this experiment was to develop a multifunctional nutraceutical composition based on ingredients of different origins (Spirulina powder (SP), bovine colostrum (BC), Jerusalem artichoke powder (JAP), and apple cider vinegar (ACV)) which possess different health benefits through their different mechanisms of action. In order to improve the functional properties of Spirulina and bovine colostrum...


Correction: Jose et al. Transferrin-Conjugated Docetaxel–PLGA Nanoparticles for...

Jose, Sajan; Cinu, Thomas A.; Sebastian, Rosmy; Shoja, M. H.; Aleykutty, N. A.; Durazzo, Alessandra; Lucarini, Massimo; Santini, Antonello

In the original publication [...]


Correction: Jose et al. Transferrin-Conjugated Docetaxel-PLGA Nanoparticles for...

Jose, Sajan; Cinu, Thomas A; Sebastian, Rosmy; Shoja, M H; Aleykutty, N A; Durazzo, Alessandra; Lucarini, Massimo; Santini, Antonello; Souto, E. B.

In the original publication [...].


Fermented food/beverage and health: current perspectives

Durazzo, Alessandra; Carocho, Márcio; Heleno, Sandrina A.; Pedrosa, Mariana C.; Ueda, Jonata Massao; Barros, Lillian; Souto, Eliana B.

Fermented products have been gaining a notable importance in recent years due to the health benefits that they can provide in relation to the initial unfermented food matrix, i.e. in the enhancement of nutrients, effect on glucose metabolism and bioactivity, the presence of probiotics in some foods. The paper gives a current analysis of the fermented food/beverage and health relationship studies present in the ...

Date: 2022   |   Origin: Biblioteca Digital do IPB

Lycopene: total-scale literature landscape analysis of a valuable nutraceutical...

Yeung, Andy Wai Kan; Choudhary, Neeraj; Tewari, Devesh; El-Demerdash, Amr; Tomczyk, Michal; Das, Niranjan; Pirgozliev, Vasil; Lucarini, Massimo

Lycopene intake from tomatoes and other food sources has multiple potential health benefits. This report aimed to evaluate the current research literature on lycopene concerning human and animal health. The electronic Web of Science Core Collection database was searched with (lycopene*) AND (health* OR illness* OR disease* OR medic* OR pharma* OR drug* OR therap*). The resulted 3972 papers were analyzed with th...


Uncaria tomentosa (Willd. ex Schult.): Focus on Nutraceutical Aspects

Nazhand, Amirhossein; Durazzo, Alessandra; Lucarini, Massimo; Silva, Amelia M.; Souto, Selma B.; Severino, Patricia; Souto, Eliana Maria Barbosa

Medicinal plants have been globally exploiting as an alternative to chemical drugs in the treatment of several diseases due to low unwanted side effects, environmentally friendly nature, and low production costs. Therefore, it is important to analyze the therapeutic properties of various medicinal plants to understand their potential bioactivity. Uncaria tomentosa is one of these medicinal plants with many heal...


Photoprotection and skin irritation effect of hydrogels containing hydroalcohol...

Batista, Cinthia M.; Queiroz, Luma A. de; Alves, Ângela V. F.; Reis, Elisiane C. A.; Santos, Fagne A.; Castro, Tailaine N.; Lima, Bruno S.

The use of natural products in sunscreen formulations as a prophylactic measure against skin cancer is receiving special attention attributed to the photoprotective and antioxidant properties of their chemical components. In this work, we describe the development of topical hydrogel formulations containing hydroalcoholic extract of red propolis (HERP), and the evaluation of the dermal sensitizing effect of the ...


Resveratrol biotechnological applications: enlightening its antimicrobial and a...

Sharifi-Rad, Javad; Quispe, Cristina; Durazzo, Alessandra; Lucarini, Massimo; Souto, Eliana B.; Santini, Antonello; Imran, Muhammad; Moussa, Ashaimaa Y.

Introduction Resveratrol (3,5,4'-trihydroxy-trans-stilbene) is a polyphenol obtained from diverse groups of plants, especially in the muscadine grape, red wine, lingonberry, cranberry and redcurrant. Resveratrol's health benefits were first highlighted in the study of the French paradox, which opened up an expansive research endeavor into this compound. Ever since, an array of pharmacological activities, includ...


Bacillus thuringiensis: From biopesticides to anticancer agents

Santos, Edclécia N.; Menezes, Lorenna P.; Dolabella, Silvio S.; Santini, Antonello; Severino, Patrícia; Capasso, Raffaele; Zielinska, Aleksandra

Bacillus thuringiensis (Bt) is a ubiquitous bacterium that produces several proteins that are toxic to different invertebrates such as insects, nematodes, mites, and also some protozoans. Among these, Cry and Cyt proteins are most explored as biopesticides for their action against agricultural pests and vectors of human diseases. In 2000, a group of researchers from Japan isolated parasporal inclusion proteins ...


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