4 documents found, page 1 of 1
Pathologic rupture of the spleen in a patient with acute myelogenous leukemia a...
Santis,Gil Cunha De; Oliveira,Luciana Correa; Ramos,Aline Fernanda; Silva,Nataly Dantas Fortes da; Falcão,Roberto PassettoRupture of the spleen can be classified as spontaneous, traumatic, or pathologic. Pathologic rupture has been reported in infectious diseases such as infectious mononucleosis, and hematologic malignancies such as acute and chronic leukemias. Splenomegaly is considered the most relevant factor that predisposes to splenic rupture. A 66-year-old man with acute myeloid leukemia evolved from an unclassified myelopro...
Sickle cell disease and pregnancy: analysis of 34 patients followed at the Regi...
Silva-Pinto,Ana Cristina; Ladeira,Simery de Oliveira Domingues; Brunetta,Denise Menezes; Santis,Gil Cunha De; Angulo,Ivan de Lucena; Covas,Dimas TadeuObjective: The objective of this study was to verify the evolution of pregnancies in sickle cell patients followed at one institution over a period of 12 years (January 2000 to June 2012). Methods: The study evaluated 34 pregnant women with sickle cell disease with a mean age of 23.9 ± 5.3 years. The incidence of obstetric complications, non-obstetric complications linked to sickle cell disease and complication...
Clinical and hematological effects of hydroxyurea therapy in sickle cell patien...
Silva-Pinto,Ana Cristina; Angulo,Ivan Lucena; Brunetta,Denise Menezes; Neves,Fabia Idalina Rodrigues; Bassi,Sarah Cristina; Santis,Gil Cunha DeCONTEXT AND OBJECTIVES Sickle cell disease (SCD) is the most common genetic disorder among people of African descent, affecting approximately 3,500 newborns each year in Brazil. Hydroxyurea (HU) is the only effective drug to treating patients with SCD, thereby reducing morbidity and mortality. The objective was to analyze the effects of HU on SCD patients at our institution. DESIGN AND SETTING Retrospective stu...
Autoimmune hemolytic anemia in HCV/HIV coinfected patients during treatment wit...
Vilar,Fernando Crivelenti; Castro,Gleusa de; Moya,Maria Janete; Martinelli,Ana de Lourdes Candolo; Santis,Gil Cunha DeTwo cases of autoimmune hemolytic anemia that occurred during the treatment of chronic hepatitis C with pegylated alpha-2a interferon and ribavirin, in HIV coinfected patients, are presented and described. The late occurrence (after six months of therapy) of this severe hemolytic anemia leads to the recommendation that hemoglobin levels should be monitored throughout the treatment period, even among patients wh...