4 documents found, page 1 of 1
Nationwide Access to Endovascular Treatment for Acute Ischemic Stroke in Portugal
Carvalho Dias, M; Soares dos Reis, R; Santos, JV; Paiva Nunes, A; Ferreira, P; Maia, B; Fragata, I; Reis, J; Ramos Lopes, J; Cruz, L; Santo, GIntroduction: Since the publication of endovascular treatment trials and European Stroke Guidelines, Portugal has re-organized stroke healthcare. The nine centers performing endovascular treatment are not equally distributed within the country, which may lead to differential access to endovascular treatment. Our main aim was to perform a descriptive analysis of the main treatment metrics regarding endovascular ...
PHACTR1 genetic variability is not critical in small vessel ischemic disease pa...
Messerschmidt, C; Foddis, M; Blumenau, S; Müller, S; Bentele, K; Holtgrewe, M; Kun-Rodrigues, C; Alonso, I; Carmo Macario, M; Morgadinho, AS; Velon, AGRecently, several genome-wide association studies identified PHACTR1 as key locus for five diverse vascular disorders: coronary artery disease, migraine, fibromuscular dysplasia, cervical artery dissection and hypertension. Although these represent significant risk factors or comorbidities for ischemic stroke, PHACTR1 role in brain small vessel ischemic disease and ischemic stroke most important survival mechan...
Pathophysiology of Blood–Brain Barrier Permeability Throughout the Different St...
Bernardo-Castro, S; Sousa, JA; Brás, A; Cecília, C; Rodrigues, B; Almendra, L; Machado, C; Santo, G; Silva, F; Ferreira, L; Santana, IThe blood-brain barrier (BBB) is a dynamic interface responsible for maintaining the central nervous system homeostasis. Its unique characteristics allow protecting the brain from unwanted compounds, but its impairment is involved in a vast number of pathological conditions. Disruption of the BBB and increase in its permeability are key in the development of several neurological diseases and have been extensive...
Familial Sneddon's syndrome
Mascarenhas, R; Santo, G; Ferro, MA; Tellechea, O; Gonçalo, Margarida; Figueiredo, AA syndrome associating Livedo Reticularis (LR) with Cerebrovascular disease (CVD) was described, in 1965, by Sneddon. It occurs sporadically, but a few familial cases of Sneddon's Syndrome (SS) have been reported, like these 3 cases that represent one of the largest number among siblings. We studied three male brothers, aged 28, 37 and 42 years, with CVD (ischaemic stroke in 2 patients and cerebral haemorrhages...