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Microevolution of a Mycobacteroides abscessus subsp. bolletii strain in a clini...
Santos, Andrea; Pinto, Miguel; Carneiro, Sofia; Silva, Sónia; Rodrigues, Irene; Munhá, João; Gomes, João Paulo; Macedo, RitaPublisher Copyright: © 2023 The Authors; Mycobacteroides abscessus complex (MAB), a fast-growing nontuberculous mycobacterium, is emerging as a significant infectious disease threat, due to both intrinsic and acquired resistance mechanisms to antibiotics and disinfectants and the need for extensive and multidrug regimens for treatment. Despite the prolonged regimens, outcomes are poor and persistence cases have...
Genome-Scale Characterization of Mycobacterium abscessus Complex Isolates from ...
Carneiro, Sofia; Pinto, Miguel; Silva, Sónia; Santos, Andrea; Rodrigues, Irene; Santos, Daniela; Duarte, Sílvia; Vieira, Luís; Gomes, João PauloThe acquisition of equipment for whole-genome sequencing used in this study was funded by the HERA (Human and Environmental Risk Assessment) project (Grant/2021/PHF/23776) supported by the European Commission through the European Centre for Disease Prevention and Control (ECDC). This work was also partially funded by the GenomePT project (POCI-01-0145-FEDER-022184) supported by COMPETE 2020 (Operational Program...
Imipenem Resistance in Clostridium difficile Ribotype 017, Portugal
Isidro, Joana; Santos, Andrea; Nunes, Alexandra; Borges, Vitor; Silva, Catarina; Vieira, Luis; Mendes, Aristides L.; Serrano, MonicaWe describe imipenem-resistant and imipenem-susceptible clinical isolates of Clostridium difficile ribotype 017 in Portugal. All ribotype 017 isolates carried an extra penicillin-binding protein gene, pbp5, and the imipenem-resistant isolates had additional substitutions near the transpeptidase active sites of pbp1 and pbp3. These clones could disseminate and contribute to imipenem resistance.
Genomic Study of a Clostridium difficile Multidrug Resistant Outbreak-Related C...
Isidro, Joana; Menezes, Juliana; Serrano, Monica; Borges, Vitor; Paixao, Pedro; Mimoso, Margarida; Martins, Filomena; Toscano, Cristina; Santos, Andrea