Funding Information: The results in this publication were produced within the GreenCoat project (project number 03EE5066A), supported by the Federal Ministry of Economic Affairs and Climate Action (BMWK), based on a resolution of the German Parliament. Publisher Copyright: © 2024 The Author(s); A novel characterization technique based on image analysis is presented, intended to complement state-of-the-art refle...
Publisher Copyright: ©2025 The Authors; Published by the American Association for Cancer Research.; Undifferentiated pleomorphic sarcoma (UPS) remains one of the most clinically aggressive and poorly characterized soft-tissue sarcoma subtypes. To uncover distinctive molecular traits for UPS, a multiomics analysis of UPS compared with leiomyosarcoma (LMS) and liposarcoma (LPS) was performed. Transcriptomic profi...
Spermatocytic tumour (ST) accounts for 1% of testicular germ cell tumours. It is an indolent neoplasm with good prognosis. In approximately 6% of STs, sarcomatous dedifferentiation may occur, portending an aggressive behaviour and representing a significant diagnostic challenge that can lead to its misdiagnosis. Herein, we report the clinicopathological features of a patient with a sarcomatoid spermatocytic tum...
Funding Information: This project has received funding from the European Union’s Horizon 2020 (European Research Council) under grant agreement No ERC-2016-CoG 725034 and was supported by the Associate Laboratory for Green Chemistry-LAQV. We also thank the support of ADEIM-FFUL (Associação para o Ensino e a Investigação em Microbiologia). Publisher Copyright: © 2023 The Author(s); Therapeutic liquid mixtures, a...
Grant No. 451-03-9/2021-14/ 200222 Grant no ERC-2016-CoG 72503; Defatted raspberry seeds were used as an alternative source of antioxidants and ellagic acid (EA) extracted using Natural deep eutectic solvents (NADES). In the preliminary study, the best NADES combination (citric acid-betaine) and the most influential variables (temperature, time, and NADES/plant ratio) were selected for the further optimization ...
Funding Information: info:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F50006%2F2020/PT Funding: This research was supported by the Science Fund of the Republic of Serbia, 6060592, Natural Deep Eutectic Solvents for Green Agri-Food Solutions—DEStiny and 7750168, Novel extracts and bioactive compounds from under-utilized resources for high-value applications—BioUtilize. This project received funding from th...
IF/00621/2015; New dianionic ionic liquids (ILs) based on carboxylic anions and ammonium cations were prepared and characterized. They were used as excipients to increase the solubility of two model oral drugs of BCS class II, ibuprofen and piroxicam. With only 0.2 mol% (≈100 mM) of [N4 1 1 2OH]2[C4H4O4], the solubility increases over 40-fold and 2-fold for ibuprofen, when compared with the parent drug for wate...
ERC-2016-CoG 725034 HE 7165/6-1 CH 1922/1-1; The use of water as a component of deep eutectic systems (DES) has raised some questions regarding its influence on the nature of the mixture. Does it form a DES or an aqueous solution and what is the role of water? In this work, the nature of citric acid:l-arginine:water mixtures was explored through phase equilibria studies and spectroscopic analysis. In a first st...
ERC-2016-CoG 725034 POCI-01-0145-FEDER 007265; What if a new technology based on therapeutic deep eutectic systems would disrupt the current treatment of major economic and socially burdensome diseases? The classical definition of eutectic systems is that they are the combination of two or more compounds that interact via hydrogen bonds, from which results a melting temperature depression in comparison with tha...