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Prognostic significance of AKT/mTOR signaling in advanced neuroendocrine tumors...

Fernandes, Isabel; Pacheco, Teresa R.; Costa, Adília; Santos, Ana C.; Fernandes, Ana R.; Santos, Mara; Oliveira, António G.; Casimiro, Sandra

Introduction: Somatostatin analogs (SSAs) are used as part of standard treatment for advanced neuroendocrine tumors (NETs). The mechanisms behind the antiproliferative action of SSAs remain largely unknown, but a connection with the mammalian target of rapamycin (mTOR) signaling pathway has been suggested. Our purpose was to evaluate the activation status of the AKT/mTOR pathway in advanced metastatic NETs and ...

Date: 2012   |   Origin: Repositório Institucional da UNL
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