6 documents found, page 1 of 1
Efeito sinérgico da associação entre L-triptofano e analgésicos não-opióides em...
Rocha, Nayrton Flávio MouraThe drug combination to reach greater clinical outcomes or reduce side effects is usual practice in the managing of several morbid conditions. The current painkillers have side effects potentially dangerous that should be monitoring during its utilization. Objective: to study the interaction between L-tryptophan and non-opioids analgesics dipyrone, ketoprofen or paracetamol, by oral or intraperitoneal route, in...
Synergistic effect of the L-tryptophan and kynurenic acid with dipyrone or para...
Rocha, Nayrton Flávio Moura; Rios, Emiliano Ricardo Vasconcelos; Carvalho, Alyne Mara Rodrigues; Freire, Leonardo Vasconcelos; Dias, Marília LeitePurpose: Our great interest in this work was study the synergism between L-tryptophan and dipyrone or paracetamol as well as the interaction of kynurenic acid (L-tryptophan metabolite) and these analgesics agents utilizing a robust methodology. Methods: We performed the writhing test induced by acetic acid in mice to evaluate the antinociceptive effect of the treatments isolated and combined (p.o. and i.p.). Do...
Evaluation of the anti-inflammatory activity of riparin II (O-methil- N-2-hidro...
Carvalho, Alyne Mara Rodrigues de; Rocha, Nayrton Flávio Moura; Vasconcelos, Leonardo Freire; Rios, Emiliano Ricardo Vasconcelos; Dias, Marília LeiteRiparin II (RipII), an alkamide isolated from the green fruit of Aniba riparia, was tested in the various animal models of inflammation to investigate its anti-inflammatory activity. Male Wistar rats (180–240 g) were treated with RipII by gavage at doses 25 or 50 mg/kg, before initiating the inflammatory responses. The tests used were paw edema induced by carrageenan, dextran, histamine or serotonin; peritoniti...
TRP and ASIC channels mediate the antinociceptive effect of citronellyl acetate
Rios, Emiliano Ricardo Vasconcelos; Rocha, Nayrton Flávio Moura; Carvalho, Alyne Mara Rodrigues; Vasconcelos, Leonardo Freire; Dias, Marília LeiteBackground: Citronellyl acetate (CAT), a monoterpene product of the secondary metabolism of plants, has been shown in the literature to possess several different biological activities. However, no antinociceptive abilities have yet been discussed. Here, we used acute pain animal models to describe the antinociceptive action of CAT. Methods: The acetic acid-induced writhing test and the paw-licking test, in whic...
Antinociceptive activity of carvacrol (5-isopropyl-2- methylphenol) in mice
Melo, Francisca Helvira Cavalcante; Rios, Emiliano Ricardo Vasconcelos; Rocha, Nayrton Flávio Moura; Citó, Maria do Carmo de OliveiraObjectives Carvacrol (5-isopropyl-2-methylphenol) is a monoterpenic phenol which is present in the essential oil of oregano and thyme.We have investigated the behavioural effects of carvacrol in animal models of pain, such as acetic acidinduced abdominal constriction, formalin and hot-plate tests in mice. The spontaneous motor activity of animals treated with carvacrol was investigated using open-field and rota...
Estudo dos efeitos farmacológicos do (-)-α-bisabolol em modelos animais de noci...
Rocha, Nayrton Flávio Moura(-)-a-bisabolol, a sesquiterpenic álcool, is commonly obtained from Matricaria chamomilla and from species of Vanillosmopsis, it was tested in animal standardized models of nociception, inflamation and gastric ulcer in mice. In this assays, (-)-a-bisabolol was used in the doses of 25 and 50 mg/Kg in the models of nociception and 100 and 200 mg/Kg in the models of inflamatiom and gastric ulcers, administered by ...