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Simvastatin assay and dissolution studies by feasible rp-hplc in tablets.
Marinho, Flávia Dias Marques; Santos, Amanda Leão dos; Soares, Cristina Duarte Vianna; Reis, Ilka Afonso; Zanon, José Carlos da CostaCommonly used HPLC acetonitrile solvent has been through a worldwide shortage with a cost increase in 2008 and 2009. In order to get around this situation, a method by RP-HPLC employing methanol and aqueous acid mobile phase was developed and validated to evaluate simvastatin. The quality control assay and dissolution studies of this lipid-lowering drug were performed in diluents methanol and 0.01 M phosphate b...
Data: 2014
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Origem: Oasisbr