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Glutamine and Alanyl-Glutamine increase RhoA expression and reduce clostridium ...
Santos, Ana Angélica Queiroz Assunção; Braga Neto, Manuel Bonfim; Oliveira, Marcelo Róseo de; Freire, Rosemayre Souza; Barros, Eduardo BedêClostridium difficile is a major cause of antibiotic-associated colitis and is associated with signicant morbidity and mortality. Glutamine (Gln) is a major fuel for the intestinal cell population. Alanyl-glutamine (Ala-Gln) is a dipeptide that is highly soluble and well tolerated. IEC-6 cells were used in the in vitro experiments. Cell morphology was evaluated by atomic force microscopy (AFM) and scanning elec...
Papel do receptor P2x7 no efeito da toxina a do Clostridium difficile em modelo...
Santos, Ana Angélica Queiroz AssunçãoClostridium difficile (C. difficile) is the major cause of colitis associated with the use of antibiotics, with significant morbidity and mortality. The enteric nervous system (ENS) is located in the gastrointestinal tract (GIT) and has an important function of regulating the digestive system. The P2X7 receptor participates in the regulation of cellular permeability, cytokine release and apoptosis, processes th...
Evaluation of the chronobiological profile and its relation with the nutritiona...
Santos, Ana Angélica Queiroz Assunção; Souza, Ana Isabel Lima de; Viana, Felipe Araújo Viana; Freire, Gildenio Estevam; Veras, Mariana De Oliveira VianaC hronobiology is responsible for studying the temporal properties of living matter, including all levels of organization, as well as the study of circadian rhythms, which are biological rhythms that oscillate around 24 hours. The objective of the present study was to reveal the chronobiological profile of night workers in an industry, as well as to detect the de gree of influence of shift work conditions on sl...
Nutriproteomics for obesity research
Brito, Fernando César Rodrigues; Lima Neto, Abelardo Barbosa Moreira; Silva, Bruno Bezerra da; Cunha, Luana Mara Silva de Castro Pacheco daThis study aimed to review findings of scientific articles which the use of proteomic tools made it possible to characterize the metabolic profile of obese individuals. We searched the electronic databases: Scielo, PubMed, Lilacs and capes. The time period was defined as 10 years, having as main keywords: proteomics, proteome, obesity, biomarkers. The use of serum proteomic techniques proposed prognostic marker...
Mapping of foods with whey protein by patental documents
Brito, Fernando César Rodrigues; Pontes, Carolinne Reinaldo; Castro, Luana Mara Silva de; Cunha, Pacheco da; Souza, Ismael Paula deThe proteins contained in whey have a wide nutritional application and present bioactive and functional well - defined characteristics. Its wide use in the food market provided specific benefits in food and nutrition area. The objective of this study was to map the foods containing the whey protein at the National Institute of Industrial Property (INPI) and Espacenet®. This search resulted in a total of 46 pa t...
Estudo das alterações morfológicas induzidas pela Toxina A, do Clostridium diff...
Santos, Ana Angélica Queiroz AssunçãoClostridium difficile is the major cause of antibiotic-associated colitis, a disease with significant morbidity and mortality. Glutamine (Gln), a non-essential aminoacid, is a major fuel for the dynamic intestinal cell population. Alanyl-glutamine (Ala-Gln) is a dipeptide that is highly soluble and well tolerated. The aim of this study was to analyze the changes induced by Clostridium difficile toxin A (TcdA) i...