8 documents found, page 1 of 1

Body image concerns in people who underwent a total laryngectomy

Abstract: Background: Body image is a potential psychological burden after total laryngectomy (TL) with devastating effects on patients’ health-related quality of life (HRQOL) and communication. This study focused on TL patients to determine the prevalence of dissatisfied body image and whether they have poorer HRQOL and difficulty adjusting to their new voice than TL patients with satisfied body image. It also...

Different Risk Profiles for Progression of Nonproliferative Diabetic Retinopath...

Introduction: Characterization of 2-year progression of different risk phenotypes in eyes with mild and moderate nonproliferative diabetic retinopathy (NPDR) in type 2 diabetes (T2D). Methods: A 2-year prospective longitudinal cohort study (CORDIS, NCT03696810) was conducted. Ophthalmological examinations were performed including best corrected visual acuity, color fundus photography and optical coherence tomog...

"In the Same Storm, but Not on the Same Boat": Children Grief During the COVID-...

COVID-19 has profoundly shaken the world and changed the lives of children and families. People around the world are mourning a sense of freedom, normalcy, and routine. However, although in the same “storm,” children are not on the same boat as adults. Children may be at a higher risk for mental health effects, given their limited capacity to understand their surroundings, cope with stressors, and control their...

“In the same storm, but not on the same boat” : children grief during the Covid...

Caloric restriction rescues yeast cells from alpha-synuclein toxicity through a...

α-Synuclein (SNCA) is a presynaptic protein that is associated with the pathophysiology of synucleinopathies, including Parkinson's disease. SNCA is a naturally aggregation-prone protein, which may be degraded by the ubiquitin-proteasome system (UPS) and by lysosomal degradation pathways. Besides being a target of the proteolytic systems, SNCA can also alter the function of these pathways further, contributing ...

The RNA-Binding Protein hnRNP K Mediates the Effect of BDNF on Dendritic mRNA M...

Brain-derived neurotrophic factor (BDNF) is an important mediator of long-term synaptic potentiation (LTP) in the hippocampus. The local effects of BDNF depend on the activation of translation activity, which requires the delivery of transcripts to the synapse. In this work, we found that neuronal activity regulates the dendritic localization of the RNA-binding protein heterogeneous nuclear ribonucleoprotein K ...

The RNA-binding protein hnRNP K mediates the effect of BDNF on dendritic mRNA m...

Brain-derived neurotrophic factor (BDNF) is an important mediator of long-term synaptic potentiation (LTP) in the hippocampus. The local effects of BDNF depend on the activation of translation activity, which requires the delivery of transcripts to the synapse. In this work, we found that neuronal activity regulates the dendritic localization of the RNA-binding protein heterogeneous nuclear ribonucleoprotein K ...

Imunohistoquímica no diagnóstico da glomerulonefrite membranosa: estudo compara...

A glomerulonefrite membranosa faz parte das doenças glomerulares que provocam glomerulonefrite crônica, apresentando-se como uma das causas da doença renal terminal. As técnicas de imunofluorescência são o gold standard no estudo imunológico desta patologia em biópsia renal, através da deteção de imunocomplexos (e.g. IgG e C3) e do seu padrão de distribuição granular característico. No entanto, a imunofluorescê...