4 documents found, page 1 of 1
Antileishmanial activity of Melampodium divaricatum and Casearia sylvestris ess...
Moreira, Raquel Regina Duarte; Santos, André Gonzaga dos; Carvalho, Flavio Alexandre; Perego, Caio Humberto; Crevelin, Eduardo JoséLeishmaniasis is a disease that affects millions of people and it is an important public health problem. The drugs currently used for the treatment of leishmaniasis present undesirable side effects and low efficacy. In this study, we evaluated the in vitro activity of Melampodium divaricatum (MD-EO) and Casearia sylvestris (CS-EO) essential oils (EO) against promastigote and amastigote forms of Leishmania amazo...
Organic cocoa extract -loaded surfactant-based systems intended to skin bioadhe...
Fonseca-Santos, Bruno; Funagoshi, Erica Emi; Oliveira, José Ricardo Soares de; Sacramento, Luis Vitor Silva do; Santos, André Gonzaga dosThis study was to develop, characterize, and evaluate the physical-chemical stability, in vitro antioxidant activity and in vitro safety profile of liquid crystalline systems (LCS) and microemulsions (MEs) with and without organic cocoa (OC) extract. LCS stabilized by surfactant polyoxyethylene 20 cetyl ether, containing water and oleic acid were studied. LCS and MEs were characterized using polarized light mic...
Evaluation of antimicrobial, cytotoxic and chemopreventive activities of carvon...
Moro, Isabela Jacob; Gondo, Gabrielle Demmany Gualberto Alexandre; Pierri, Elaíse Gonçalves; Pietro, Rosemeire Cristina Linharis RodriguesConsidering the reported activity of carvone in the literature, this study aimed to evaluate the antimicrobial, cytotoxic and chemopreventive activities of (+)- and (-)-carvone, (+)- and (-)- hydroxydihydrocarvone and α,β-epoxycarvone. (+)-Hydroxydihydrocarvone (HC+), (-)-hydroxydihydrocarvone (HC-) and α,β-epoxycarvone (EP) were obtained by synthesis using (+)-carvone (C+) or (-)-carvone (C-) as precursors. Th...
Counteracting effects on free radicals and histological alterations induced by ...
Araújo, Éverton José Ferreira de; Oliveira, Guilherme Antônio Lopes de; Sousa, Lívia Queiroz de; Bolzani, Vanderlan da Silva; Cavalheiro, Alberto JoséCasearia sylvestris Swartz is a medicinal plant widely distributed in Brazil. It has anti-inflammatory, antiulcer and antitumor activities and is popularly used to treat snakebites, wounds, diarrhea, flu and chest colds. Its leaves are rich in oxygenated tricyclic cis -clerodane diterpenes, particulary casearins. Herein, we evaluated the antioxidant activities of a fraction with casearins (FC) isolated from C. ...