Encontrados 11 documentos, a visualizar página 1 de 2
Peptidases Are Potential Targets of Copper(II)-1,10-Phenanthroline-5,6-dione Co...
Rigo, Graziela Vargas; Cardoso, Fernanda Gomes; Pereira, Matheus Mendonça; Devereux, Michael; McCann, Malachy; Santos, André L. S.; Tasca, TianaTrichomonas vaginalis is responsible for 156 million new cases per year worldwide. When present asymptomatically, the parasite can lead to serious complications, such as development of cervical and prostate cancer. As infection increases the acquisition and transmission of HIV, the control of trichomoniasis represents an important niche for the discovery and development of new antiparasitic molecules. This urog...
Corrigendum to Analysis of the mechanisms of action of isopentyl caffeate again...
Oliveira, Simone S. C.; Marques, Carine S. F.; Sousa, Damião P. de; Andrade, Luciana N.; Fricks, Alini T.; Jain, Sona; Branquinha, Marta H.Corrigendum to “Analysis of the mechanisms of action of isopentyl caffeate against Leishmania”. Biochimie 189 (2021) 158–167
Are Nanobiosensors an Improved Solution for Diagnosis of Leishmania?
Jain, Sona; Santana, Wanessa; Dolabella, Silvio S.; Santos, André L. S.; Souto, Eliana B.; Severino, PatríciaLeishmaniasis is one of the deadliest neglected tropical diseases affecting 12-15 million people worldwide, especially in middle- and low-income countries. Rapid and accurate diagnosis of the disease is important for its adequate management and treatment. Several techniques are available for the diagnosis of leishmaniasis. Among these, parasitological and immunological tests are most widely used. However, in mo...
Cashew Gum (Anacardium occidentale) as a Potential Source for the Production of...
Loureiro, Kahynna C.; Jäger, Alessandro; Pavlova, Ewa; Lima-Verde, Isabel B.; Štěpánek, Petr; Sangenito, Leandro S.; Santos, André L. S.Every year, more than thirty thousand tons of Cashew gum (Anacardium occidentale, family: Anacardiaceae) are produced in Brazil; however, only a small amount is used for different applications in foodstuff and in pharmaceutical industries. As a raw material for the production of drug delivery systems, cashew gum is still regarded as an innovative compound worth to be exploited. In this work, cashew gum was extr...
Analysis of the mechanisms of action of isopentenyl caffeate against Leishmania
Oliveira, Simone S. C.; Marques, Carine S. F.; Sousa, Damião P. de; Andrade, Luciana N.; Fricks, Alini T.; Jain, Sona; Branquinha, Marta H.Leishmaniasis is a neglected parasitic disease for which the conventional treatment can be considered inefficient and extremely aggressive, generating several and severe side effects. Therefore, the discovery of new drug candidates is important for the improvement in the quality of life of patients. Previously, we reported the promising results of isopentyl caffeate (ICaf) against Leishmania chagasi (agent of v...
Overcoming multi-resistant leishmania treatment by nanoencapsulation of potent ...
Oliveira, Simone S. C.; Ferreira, Carine S.; Branquinha, Marta H.; Santos, André L. S.; Chaud, Marco V.; Jain, Sona; Cardoso, Juliana C.Leishmaniasis corresponds to a group of neglected tropical diseases caused by flagellated protozoa belonging to the Leishmania genus. This widely spread illness is found in over 90 countries in the tropic and sub-tropic regions and also in southern Europe. As parasites exclusively infect the highly phagocytic cells (macrophages), this aspect can be exploited for targeted delivery making use of nanoparticles. Dr...
Citrus sinensis essential oil-based microemulsions: green synthesis, characteri...
Souza, Jônatas; Santos, Glaciene S.; Barbosa, Thallysson C.; Santos, André L. S.; Menezes, Lucas G.; Andrade, Luciana N.; Bani, CristianeThe aim of this study was the development and characterization of a new microemulsion composed of sweet orange (Citrus sinensis L.) essential oils (EOCs) and evaluate its antibacterial and larvicide profiles. The optimal combination of EOCs, surfactant (Kolliphor EL), and water was achieved using a ternary phase diagram. EOCs were obtained from orange peel by steam-distillation and analyzed by gas chromatograph...
Exploring innovative Leishmaniasis treatment: drug targets from pre-clinical to...
Santana, Wanessa; de Oliveira, Simone S. C.; Ramos, Mariana H.; Santos, André L. S.; Dolabella, Silvio S.; Souto, Eliana B.; Severino, PatríciaLeishmaniasis is a group of tropical diseases caused by parasitic protozoa belonging to the genus Leishmania. The disease is categorized in cutaneous leishmaniasis (CL), mucocutaneous leishmaniasis (MCL), and visceral leishmaniasis (VL). The conventional treatment is complex and can present high toxicity and therapeutic failures. Thus, there is a continuing need to develop new treatments. In this review, we foc...
Are nanobiosensors an improved solution for diagnosis of Leishmania?
Jain, Sona; Santana, Wanessa; Dolabella, Silvio S.; Santos, André L. S.; Souto, Eliana B.; Severino, PatríciaLeishmaniasis is one of the deadliest neglected tropical diseases affecting 1215 million people worldwide, especially in middle- and low-income countries. Rapid and accurate diagnosis of the disease is important for its adequate management and treatment. Several techniques are available for the diagnosis of leishmaniasis. Among these, parasitological and immunological tests are most widely used. However, in mos...
β-cyclodextrin/isopentyl caffeate inclusion complex: synthesis, characterizatio...
Marques, Carine S. F.; Barreto, Nathalia S.; Oliveira, Simone S. C. de; Santos, André L. S.; Branquinha, Marta H.; Sousa, Damião P. de; Castro, MayaraIsopentyl caffeate (ICaf) is a bioactive ester widely distributed in nature. Our patented work has shown promising results of this molecule against Leishmania. However, ICaf shows poor solubility, which limits its usage in clinical settings. In this work, we have proposed the development of an inclusion complex of ICaf in -cyclodextrin (-CD), with the aim to improve the drug solubility, and thus, its bioavailab...