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Preconditioning with a novel metallopharmaceutical NO donor in anesthetized rat...

Oriá, Reinaldo Barreto; Lopes, Luiz Gonzaga de França; Brito, Gerly Anne de Castro; Santos, Armenio Aguiar dos; Vasconcelos, Raquel Cavalcante de

Rut-bpy is a novel nitrosyl–ruthenium complex releasing NO into the vascular system. We evaluated the effect of Rut-bpy (100 mg/kg) on a rat model of brain stroke. Forty rats were assigned to four groups (Saline solution [SS], Rut-bpy, SS?ischemia–reperfusion [SS?I/ R] and Rut-bpy?ischemia–reperfusion [Rut-bpy?I/R]) with their mean arterial pressure (MAP) continuously monitored. The groups were submitted (SS?I/...

Date: 2013   |   Origin: Oasisbr

Talking about bioelectrical potentials using rings of the mesenteric artery wit...

Ribeiro-Filho, Helder Veras; Brito, Teresinha Silva de; Lima, F. J. B.; Pinho, J. P. M.; Sousa, D. F.; Silva, Moisés Tolentino Bento da

In the present study, a practical activity is proposed to adopt an experimental approach to demonstrate the relationship between the equilibrium potential for K and transmembrane electrical potential without glass micropipettes. A conventional setup for recording contractile activity of isolated smooth muscle preparations was used based on the events elegantly described by Somlyo and Somlyo in the 1960s. They s...

Date: 2013   |   Origin: Oasisbr

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