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Spiro-β-lactam BSS-730A Displays Potent Activity against HIV and Plasmodium

Bártolo, Inês; Santos, Bruna S; Fontinha, Diana; Machado, Marta; Francisco, Denise; Sepodes, Bruno; Rocha, João; Mota-Filipe, Hélder; Pinto, Rui

The high burden of malaria and HIV/AIDS prevents economic and social progress in developing countries. A continuing need exists for development of novel drugs and treatment regimens for both diseases in order to address the tolerability and long-term safety concerns associated with current treatment options and the emergence of drug resistance. We describe new spiro-β-lactam derivatives with potent (nM) activit...

Date: 2021   |   Origin: Estudo Geral - Universidade de Coimbra
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